Reactive oxygen species regulate a balance between mitotic catastrophe and apoptosis

被引：9
|
作者：
Sorokina, Irina V. [1 ]
Denisenko, Tatiana V. [1 ]
Imreh, Gabriela [2 ]
Gogvadze, Vladimir [1 ,2 ]
Zhivotovsky, Boris [1 ,2 ]
机构：
[1] Moscow MV Lomonosov State Univ, Fac Fundamental Med, Moscow 11999, Russia
[2] Karolinska Inst, Inst Environm Med, Div Toxicol, Box 210, S-17177 Stockholm, Sweden
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2016年 / 81卷
基金：
瑞典研究理事会; 俄罗斯科学基金会;
关键词：
Mitotic catastrophe; Apoptosis; Mitochondria; Reactive oxygen species; Tumor;
D O I：
10.1016/j.biocel.2016.11.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitotic catastrophe (MC) is a sequence of events resulting from premature or inappropriate entry of cells into mitosis that can be caused by chemical or physical stresses. There are several observations permitting to define MC as an oncosuppressive mechanism. MC can end up in apoptosis, necrosis or senescence. Here we show that the anticancer drug doxorubicin triggers DNA damage and MC independently of ROS production. In contrast, doxorubicin-induced apoptosis was found to be ROS-dependent. Antioxidants NAC or Trolox suppressed apoptosis, but facilitated MC development. Our data demonstrate that evasion of apoptosis and subsequent stimulation of MC can contribute to tumor cell elimination improving anticancer therapy. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：133 / 136
页数：4
相关论文
共 50 条
  • [21] Flubendazole induces mitotic catastrophe and apoptosis in melanoma cells
    Canova, K.
    Rozkydalova, L.
    Vokurkova, D.
    Rudolf, E.
    TOXICOLOGY IN VITRO, 2018, 46 : 313 - 322
  • [22] Reactive oxygen species regulate autophagy in COPD myotubes in vitro
    Pomies, Pascal
    Blaquiere, Marine
    Gouzi, Fares
    Maury, Jonathan
    Mercier, Jacques
    Hayot, Maurice
    EUROPEAN RESPIRATORY JOURNAL, 2015, 46
  • [23] Reactive Oxygen Species (ROS) regulate intracellular mitochondrial movement
    Saotome, Masao
    Hajnoczky, Gyorgy
    Hayashi, Hideharu
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2008, 45 : S23 - S23
  • [24] HIF and reactive oxygen species regulate oxidative phosphorylation in cancer
    Hervouet, Eric
    Cizkova, Alena
    Demont, Jocelyne
    Vojtiskova, Alena
    Pecina, Petr
    Hal, Nicole L. W. Franssen-van
    Keijer, Jaap
    Simonnet, Helene
    Ivanek, Robert
    Kmoch, Stanislav
    Godinot, Catherine
    Houstek, Josef
    CARCINOGENESIS, 2008, 29 (08) : 1528 - 1537
  • [25] Reactive Oxygen Species Regulate Nucleostemin Oligomerization and Protein Degradation
    Huang, Min
    Whang, Patrick
    Chodaparambil, Jayanth V.
    Pollyea, Daniel A.
    Kusler, Brenda
    Xu, Liwen
    Felsher, Dean W.
    Mitchell, Beverly S.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (13) : 11035 - 11046
  • [26] Reactive oxygen species posttranscriptionally regulate thioredoxin protein stability
    Hoffmann, J
    Tischler, V
    Haendeler, J
    CIRCULATION, 2002, 106 (19) : 50 - 50
  • [27] Reactive Oxygen Species Regulate Spontaneous and Fas-Mediated Apoptosis in SBDS-Deficient Cells.
    Ambekar, Chhaya
    Das, Bikul
    Yeger, Herman, Sr.
    Dror, Yigal
    BLOOD, 2008, 112 (11) : 709 - 710
  • [28] Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis
    Jiang, Jianfei
    Huang, Zhentai
    Zhao, Qing
    Feng, Weihong
    Belikova, Natalia A.
    Kagan, Valerian E.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 368 (01) : 145 - 150
  • [29] Induction of reactive oxygen species-dependent mitotic arrest and apoptosis by sulforaphane in human bladder cancer 5637 cells
    Choi, Yung Hyun
    CANCER RESEARCH, 2014, 74 (19)
  • [30] Reactive oxygen species as mediators of photoreceptor apoptosis in vitro
    Carmody, RJ
    McGowan, AJ
    Cotter, TG
    EXPERIMENTAL CELL RESEARCH, 1999, 248 (02) : 520 - 530
12345