Efficacy of autologous peripheral blood stem cell transplantation in POEMS syndrome with polyneuropathy

被引：17
|
作者：
Imai, Noboru [1 ]
Kitamura, Eiji [1 ]
Tachibana, Takayoshi [2 ]
Konishi, Takashi [1 ]
Suzuki, Youji [1 ]
Serizawa, Masahiro [1 ]
Okabe, Takashi [1 ]
Fujita, Hiroyuki [2 ]
机构：
[1] Shizuoka Red Cross Hosp, Dept Neurol, Shizuoka, Japan
[2] Shizuoka Red Cross Hosp, Dept Hematol, Shizuoka, Japan
来源：
INTERNAL MEDICINE | 2007年 / 46卷 / 03期
关键词：
POEMS syndrome; polyneuropathy; autologous peripheral blood stem cell transplantation; vascular endothelial growth factor; monoclonal gammopathy;
D O I：
10.2169/internalmedicine.46.1713
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
POEMS syndrome (POEMS) is a rare multi-system disease which is typically associated with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. We report herein a case of POEMS with progressive polyneuropathy resistant to high-dose intravenous immunoglobulin therapy who experienced improvement in polyneuropathy after the administration of high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation. Improvements in polyneuropathy remain despite recognition of monoclonal gammopathy by immunofixation as of 1 year after treatment. We demonstrated that autologous peripheral blood stem cell transplantation can improve clinical symptoms and signs due to polyneuropathy in POEMS even without achieving complete remission.
引用
收藏
页码：135 / 138
页数：4
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