Efficacy of autologous peripheral blood stem cell transplantation in POEMS syndrome with polyneuropathy

被引：17

作者：

Imai, Noboru ^{[1
]}

Kitamura, Eiji ^{[1
]}

Tachibana, Takayoshi ^{[2
]}

Konishi, Takashi ^{[1
]}

Suzuki, Youji ^{[1
]}

Serizawa, Masahiro ^{[1
]}

Okabe, Takashi ^{[1
]}

Fujita, Hiroyuki ^{[2
]}

机构：

[1] Shizuoka Red Cross Hosp, Dept Neurol, Shizuoka, Japan

[2] Shizuoka Red Cross Hosp, Dept Hematol, Shizuoka, Japan

来源：

INTERNAL MEDICINE | 2007年 / 46卷 / 03期

关键词：

POEMS syndrome; polyneuropathy; autologous peripheral blood stem cell transplantation; vascular endothelial growth factor; monoclonal gammopathy;

D O I：

10.2169/internalmedicine.46.1713

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

POEMS syndrome (POEMS) is a rare multi-system disease which is typically associated with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. We report herein a case of POEMS with progressive polyneuropathy resistant to high-dose intravenous immunoglobulin therapy who experienced improvement in polyneuropathy after the administration of high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation. Improvements in polyneuropathy remain despite recognition of monoclonal gammopathy by immunofixation as of 1 year after treatment. We demonstrated that autologous peripheral blood stem cell transplantation can improve clinical symptoms and signs due to polyneuropathy in POEMS even without achieving complete remission.

引用

页码：135 / 138

页数：4

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