Melatonin Strengthens a Chemotherapeutic Effect of Cytarabin in HL-60 Cells

被引：3
|
作者：
Lomovsky, A., I [1 ]
Baburina, Yu L. [1 ]
Kobyakova, M., I [1 ]
Fadeev, R. S. [1 ]
Akatov, V. S. [1 ]
Krestinina, O., V [1 ]
机构：
[1] Russian Acad Sci, Inst Theoret & Expt Biophys, Ul Inst Skaya 3, Pushchio 142290, Moscow Oblast, Russia
来源：
BIOLOGICHESKIE MEMBRANY | 2020年 / 37卷 / 02期
关键词：
melatonin; cytarabine; acute promyelocytic leukemia; apoptosis; BENZODIAZEPINE-RECEPTOR LIGANDS; DEPENDENT ANION CHANNEL; CANCER; BINDING; DEATH; RAT;
D O I：
10.31857/S0233475519060070
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We investigated the combined effect of melatonin (MEL) and cytarabin (CYT) at a low concentration on acute promyelocytic leukemia cells HL-60. A combined application of these substances led to a decrease in the number of cells by 70% and in the index of mitotic activity, by 75%. A combined effect of MEL and CYT also contributed to a decrease in the expression of mitochondrial proteins. The mitochondrial isoform of VDAC1 can be a target in the treatment of various tumors. A combined application of MEL and CYT at a low concentration (2 nM) reduced the expression of VDAC1. MEL in combination with CYT exerted a similar effect on the expression of the translocator protein (TSPO) and anti-apoptotic protein Bcl-2. The results show that MEL is able to produce a synergistic effect when combined with CYT, thereby increasing the effectiveness of its antitumor action.
引用
收藏
页码：103 / 109
页数：7
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