Effect of quercetin on cell cycle of HL-60 cells

被引：1
|
作者：
康铁邦 [1 ]
梁念慈 [1 ]
机构：
[1] 广东医学院医用生物化学研究所
来源：
中国药理学与毒理学杂志 | 1998年 / 03期
关键词：
细胞株.HL－60; 黄酮类; 槲皮素; 细胞周期;
D O I：
暂无
中图分类号：
R966 [分子药理学];
学科分类号：
100602 ; 100706 ;
摘要：
本文报道了槲皮素对人早幼粒白血病细胞株ＨＬ－６０细胞的增殖和细胞周期的影响．结果表明槲皮素能抑制ＨＬ－６０细胞的增殖，呈剂量依赖关系，当槲皮素作用２４，４８，７２ｈ后，其ＩＣ５０分别为４６．６，２８．７，１４．９μｍｏｌ·Ｌ－１．流式细胞仪分析表明，槲皮素能明显增加ＨＬ－６０的Ｇ２－Ｍ期细胞，而相对减少Ｇ０／Ｇ１细胞之百分比，且呈剂量依赖关系，当去除槲皮素时，该作用是可逆的．结果表明槲皮素对肿瘤细胞的生长抑制作用可能与其对细胞周期的影响有关．
引用
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页码：7 / 9
页数：3
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