Homothety ratio of airway diameters and site of airway resistance in healthy and COPD subjects

被引:10
|
作者
Bokov, Plamen [1 ,2 ,3 ]
Mauroy, Benjamin [4 ]
Mahut, Bruno [1 ,3 ]
Delclaux, Christophe [1 ,3 ,5 ,6 ]
Flaud, Patrice [2 ]
机构
[1] Hop Europeen Georges Pompidou, AP HP, Serv Physiol Clin Dyspnee, Paris, France
[2] Univ Paris Diderot, CNRS, UMR 7057, Lab Mat & Syst Complexes MSC, Paris, France
[3] Mosquito Resp Res Grp, Paris, France
[4] Univ Nice Sophia Antipolis, CNRS, Lab JA Dieudonne, UMR 7351, F-06189 Nice, France
[5] Hop Europeen Georges Pompidou, CIC Plurithernat 9201, Paris, France
[6] Univ Paris 05, Paris, France
关键词
Airway; Chronic obstructive pulmonary disease; Homothety; Resistance; Remodeling; OBSTRUCTIVE PULMONARY-DISEASE; BRONCHIAL TREE; COMPUTED-TOMOGRAPHY; FLOW LIMITATION; PRESSURE DROP; MODELS; LUNG; PREDICTION;
D O I
10.1016/j.resp.2013.10.015
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Our objective was to evaluate whether a decrease in the homothety ratio (h: diameter of child/parent bronchus, constant over generations) explains the shift in airway resistance toward periphery in chronic obstructive pulmonary disease (COPD). Using a validated computational model of fluid motion, we determined that reduced values of is (<0.76) were associated with a shift in resistance toward periphery. The calculated luminal diameters of terminal bronchioles using normal is (0.80-0.85) or reduced h (0.70-0.75) fitted well with measured micro-CT values obtained by McDonough et al. (N. Engl. J. Med., 2011; 365:1567-75) in control and COPD patients, respectively. A semi-analytic formula of resistance using tracheal dimensions and is was developed, and using experimental data (tracheal area and is from patients [Bokov et al., Respir. Physiol. Neurobiol., 2010; 173:1-10]), we verified the agreement between measured and calculated resistance (r=0.42). In conclusion, the remodeling process of COPD may reduce h and explain the shift in resistance toward lung periphery. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:38 / 43
页数:6
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