SYNTHETIC APPROACHES TO 3,3′-BIINDOLYL AND 3,3′-BIINDAZOLYL DERIVATIVES

被引：4

作者：

Nakhai, Azadeh ^{[1
]}

Bergman, Jan ^{[1
]}

机构：

[1] Karolinska Inst, Dept Biosci & Nutr, Unit Organ Chem, SE-14157 Huddinge, Sweden

来源：

HETEROCYCLES | 2014年 / 88卷 / 01期

关键词：

3,3 '-Biindolyl; 3,3 '-Biindazolyl; Stille Cross-Coupling Reaction; Tellurium Compound; Oxidative Coupling Reaction; COUPLING REACTIONS; N-ACETYLATION; 3-IODOINDAZOLES; CHEMISTRY; CHLORIDE; GLYOXAL; INDOLES;

D O I：

10.3987/COM-13-S(S)17

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper new syntheses of 3,3'-biindolyl and 3,3'-biindazolyl derivatives are described. Formation of 3,3'-biindolyl derivatives by oxidative coupling of N-acetylindole with TeCl4 gave a good yield, while attempt to use the same reaction conditions for synthesis of 3,3'-biindazolyl derivatives failed. However, conversion of 3-haloindazole derivatives to its trimethylstannane derivative, followed by palladium-catalyzed Stille cross-coupling reaction, resulted in formation of 3,3'-biindazolyl derivatives.

引用

页码：309 / 318

页数：10

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