Tumor necrosis factor-α: a new mechanism of ischemic ventricular fibrillation?

被引：5
|
作者：
Xiao Hua [1 ]
Liao Yu-hua [1 ]
Chen Zhi-jian [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Inst Cardiol,Lab Cardiovasc Immunol, Wuhan 430022, Hubei, Peoples R China
来源：
CHINESE MEDICAL JOURNAL | 2008年 / 121卷 / 18期
关键词：
ischemic ventricular fibrillation; tumor necrosis factor-alpha; arrhythmias; cardiac;
D O I：
10.1097/00029330-200809020-00017
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ventricular tachyarrhythmia arising from myocardial ischemia and infarction is a major cause of sudden cardiac death. 38,39 VF endangers seriously the life of patients with ischemic heart diseases, but its mechanism is still not clear. We suggest TNF-α be a novel substrate of ischemic VF, a new mechanism for ischemic VF. If it is confirmed, how is ischemic VF initiated and what's a substrate for the maintenance of this disease can be clarified. Besides, TNF-α will be a new target for the therapy of ischemic VF. If the secretion and expression of TNF-α in the ischemic myocardium are inhibited, ischemic VF may be relieved. It would be a significant contribution to the protection of human health if it comes true.
引用
收藏
页码：1848 / 1851
页数：4
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