Subjective cognitive decline at the pre-dementia stage in Alzheimer's disease

There is increasing effort to define at-risk populations by Alzheimer's dementia. The condition of mild cognitive impairment (MCI) is defined by cognitive impairment on standard tests and experienced cognitive decline. The amnestic subtype of mild cognitive impairment has the highest prediction accuracy for dementia. Among different memory tests; the "Free and Cued Selective Reminding Test" is the most specific for Alzheimer's disease at the pre-dementia stage (prodromal Alzheimer's disease). Recently, increasing effort has been undertaken to characterize subjective cognitive decline as the first symptomatic manifestation of Alzheimer's disease. There is increasing evidence that for an over-representation Alzheimer's disease typical biomarker changes in elderly individuals with subjective cognitive decline. Current efforts focus on the standardization of assessment of subjective cognitive decline to elaborate its potential role as a predictor for dementia and Alzheimer's disease.