Nitrogen Containing Privileged Structures and their Solid Phase Combinatorial Synthesis

被引：0

作者：

Verma, Amit ^{[1
]}

Yadav, Mange Ram ^{[1
]}

Giridhar, Rajani ^{[1
]}

Prajapati, Navnit ^{[1
]}

Tripathi, Avinash C. ^{[2
]}

Saraf, Shailendra K. ^{[3
]}

机构：

[1] Maharaja Sayajirao Univ Baroda, Dept Pharm, Fac Engn & Technol, Vadodara 390001, Gujarat, India

[2] Babu Banarasi Northern India Inst Technol, Fac Pharm, Lucknow 227105, Uttar Pradesh, India

[3] Inst Technol, Lucknow 227105, Uttar Pradesh, India

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2013年 / 16卷 / 05期

关键词：

Benzodiazepine; combinatorial synthesis; cyclic peptides; nitrogen heterocyclics; privileged structures; purines and pyrimidines; solid-phase synthesis; GROWTH-FACTOR RECEPTOR; ALPHA-KETOHETEROCYCLIC INHIBITORS; POLYMER-SUPPORTED SYNTHESIS; TYROSINE KINASE INHIBITORS; HUMAN NEUTROPHIL ELASTASE; METALLO-BETA-LACTAMASE; BIOLOGICAL-ACTIVITY; PHARMACOKINETIC PROPERTIES; ANTIINFLAMMATORY ACTIVITY; HIGH-AFFINITY;

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The existence of preferred molecular scaffolds that possess inherent biological activity, called privileged structures, is now well recognized. Such privileged structures not only provide enhanced drug-like properties but also give new hits for developing leads. The synthesis of combinatorial libraries, especially with the insertion of privileged substructures into heterocyclic moieties containing nitrogen, provides for a greater probability of the discovery of novel lead compounds using chemical transformation. The review focuses on the progress in the solid-phase synthetic strategies of nitrogen containing privileged structures over the years.

引用

页码：345 / 393

页数：49

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