RHODIUM-CATALYZED SYNTHESIS OF BENZOFURANS BY THE REACTION OF KETONES AND O-DIFLUOROBENZENES

被引：5
|
作者：
Arisawa, Mieko [1 ]
Nakane, Soichiro [1 ]
Kuwajima, Manabu [1 ]
Yamaguchi, Masahiko [1 ]
机构：
[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Organ Chem, Sendai, Miyagi 9808578, Japan
来源：
HETEROCYCLES | 2012年 / 86卷 / 02期
关键词：
Benzofuran; o-Difluorobenzene; Polyfluorinated Benzofuran; Rhodium-Catalyzed Reaction; alpha-Arylation; ONE-POT SYNTHESIS; ALPHA-ARYLATION; INHIBITORS; OLIGOSTILBENES; DERIVATIVES; CHEMISTRY;
D O I：
10.3987/COM-12-S(N)57
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the presence of catalytic amounts of RhH(PPh3)(4) and 1,2-bis(diphenylphosphino)ethane (dppe), ketones reacted with o-difluorobenzenes giving benzofurans in high yields. The alpha-arylation of ketones and furan cyclization proceeded without using a base. Benzofuran cyclization was applied to substituted pentafluorobenzenes to give 6-substituted-4,5,7-trifluorobenzofuranes.
引用
收藏
页码：1103 / 1118
页数：16
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