There's plenty of room at the forum: Potential risks and safety assessment of engineered nanomaterials

被引:27
|
作者
Fadeel, Bengt [1 ]
Kagan, Valerian [2 ]
Krug, Harald [3 ]
Shvedova, Anna [4 ,5 ]
Svartengren, Magnus [6 ,7 ]
Tran, Lang [8 ]
Wiklund, Lars [9 ,10 ]
机构
[1] Karolinska Inst, Inst Environm Med, Div Biochem Toxicol, Cell Death Res Grp, S-17177 Stockholm, Sweden
[2] Univ Pittsburgh, Ctr Free Rad & Antioxidant Hlth, Dept Environm & Occupat Hlth, Pittsburgh, PA USA
[3] Swiss Fed Labs Mat Testing & Res EMPA, Div Mat Sci & Technol, St Gallen, Switzerland
[4] NIOSH, Pathol & Physiol Res Branch, Hlth Effects Lab Div, Morgantown, WV USA
[5] W Virginia Univ, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA
[6] Karolinska Univ Hosp, Stockholm Cty Council, Div Occupat & Environm Hlth, Stockholm, Sweden
[7] Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden
[8] Inst Occupat Med, Edinburgh EH8 9SV, Midlothian, Scotland
[9] Swedish Soc Toxicol SFT, Stockholm, Sweden
[10] Regulatory Safety Sci RegSafe, Stockholm, Sweden
关键词
Nanotoxicology; carbon nanotubes; inflammation; pulmonary exposure; risk assessment;
D O I
10.1080/17435390701565578
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The celebrated physicist and Nobel laureate Richard Feynman was the first to predict the opportunities presented by the manipulation of matter at the level of individual atoms and molecules. Today, almost 50 years after his classic lecture on the wonders of the small world, the evolving nanotechnologies have the potential to bring about major changes in the lives of citizens. However, the very same properties that make engineered nanomaterials so promising from a technological perspective, such as their high degree of reactivity and the ability to cross biological barriers, could also make these novel materials harmful to human health and the environment. Therefore, exploitation of the full potential of the nanotechnologies requires close attention to safety issues. The 1st Nobel Forum mini-symposium on nanotoxicology was recently held in Stockholm, Sweden, and the program was devoted to the topic of definitions and standardization in nanotoxicological research, as well as nano-specific risk assessment and regulatory/legislative issues. Examples of recent and ongoing studies of carbon-based nanomaterials, including single-walled carbon nanotubes, using a wide range of in vitro and in vivo model systems were also presented. The current review will provide some highlights and conclusions from this exciting meeting.
引用
收藏
页码:73 / 84
页数:12
相关论文
共 50 条
  • [21] Creative use of analytical techniques and high-throughput technology to facilitate safety assessment of engineered nanomaterials
    Qi Liu
    Xiang Wang
    Tian Xia
    Analytical and Bioanalytical Chemistry, 2018, 410 : 6097 - 6111
  • [22] CDER Risk Assessment Exercise to Evaluate Potential Risks from the Use of Nanomaterials in Drug Products
    Cruz, Celia N.
    Tyner, Katherine M.
    Velazquez, Lydia
    Hyams, Kenneth C.
    Jacobs, Abigail
    Shaw, Arthur B.
    Jiang, Wenlei
    Lionberger, Robert
    Hinderling, Peter
    Kong, Yoon
    Brown, Paul C.
    Ghosh, Tapash
    Strasinger, Caroline
    Suarez-Sharp, Sandra
    Henry, Don
    Van Uitert, Maat
    Sadrieh, Nakissa
    Morefield, Elaine
    AAPS JOURNAL, 2013, 15 (03): : 623 - 628
  • [23] CDER Risk Assessment Exercise to Evaluate Potential Risks from the Use of Nanomaterials in Drug Products
    Celia N. Cruz
    Katherine M. Tyner
    Lydia Velazquez
    Kenneth C. Hyams
    Abigail Jacobs
    Arthur B. Shaw
    Wenlei Jiang
    Robert Lionberger
    Peter Hinderling
    Yoon Kong
    Paul C. Brown
    Tapash Ghosh
    Caroline Strasinger
    Sandra Suarez-Sharp
    Don Henry
    Maat Van Uitert
    Nakissa Sadrieh
    Elaine Morefield
    The AAPS Journal, 2013, 15 : 623 - 628
  • [24] Nanoparticle Emission Assessment Technique (NEAT) for the Identification and Measurement of Potential Inhalation Exposure to Engineered Nanomaterials - Part A
    Methner, M.
    Hodson, L.
    Geraci, C.
    JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE, 2010, 7 (03) : 127 - 132
  • [25] Assessment of the toxic potential of engineered metal oxide nanomaterials using an acellular model: citrated rat blood plasma
    Gormley, Patrick Thomas
    Callaghan, Neal Ingraham
    MacCormack, Tyson James
    Dieni, Christopher Anthony
    TOXICOLOGY MECHANISMS AND METHODS, 2016, 26 (08) : 601 - 610
  • [26] Safety Assessment and Potential Risks of the Glucagon Stimulation Test in the Diagnosis of Secondary Adrenal Insufficiency
    Ach, Taieb
    Ben Abdelkrim, Asma
    Hasni, Yosra
    Saad, Ghada
    Kacem, Maha
    Chaieb, Molka
    Zaouali, Monia
    Maaroufi, Amel
    Ach, Koussay
    CURRENT DRUG SAFETY, 2022, 17 (01) : 59 - 63
  • [27] In Response: Measurement science challenges that complicate the assessment of the potential ecotoxicological risks of carbon nanomaterials-A governmental perspective
    Petersen, Elijah J.
    ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2015, 34 (05) : 955 - 957
  • [28] There's No Escaping Patient Safety: Implementation and Assessment of a Patient Safety Medical Escape Room for Pediatric Residents
    Congdon, Morgan
    Galligan, Meghan M.
    Hart, Jessica
    ACADEMIC PEDIATRICS, 2024, 24 (03) : 544 - 546
  • [29] A target safety assessment of the potential toxicological risks of targeting plasmepsin IX/X for the treatment of malaria
    Barber, Jane
    Sikakana, Phumzile
    Sadler, Claire
    Baud, Delphine
    Valentin, Jean-Pierre
    Roberts, Ruth
    TOXICOLOGY RESEARCH, 2021, 10 (02) : 203 - 213
  • [30] Insights into the potential effects of released engineered nanomaterials from polymer nanocomposites: environmental issues and future activities for risk assessment and management
    Francisco Aznar-Mollá
    Carlos Fito-López
    Jose Antonio Heredia Alvaro
    Journal of Nanoparticle Research, 2021, 23