Synthesis, Crystal Structure and Biological Evaluation of 4, 5, 6, 7-tetrahydropravastatin as HMG-CoA Reductase Inhibitor

被引：1

作者：

Li, Jing ^{[1
]}

Li, Huan ^{[1
]}

Zhang, Lei ^{[1
]}

机构：

[1] S China Univ Technol, Sch Biosci & Bioengn, Guangzhou Higher Educ Mega Ctr, Guangzhou 510006, Guangdong, Peoples R China

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2011年 / 8卷 / 09期

关键词：

Crystal structure; HMG-CoA reductase; hydrogenation; pravastatin; 4; 5; 6; 7-tetrahydropravastatin; COENZYME-A REDUCTASE; THERAPY;

D O I：

10.2174/157018011797200876

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

4, 5, 6, 7-Tetrahydropravastatin and its sodium salt as the hydrogenated derivatives of pravastatin were evaluated as HMG-CoA reductase inhibitor in vitro and in vivo, and they exhibited similar antihyperlipidaemic activity to pravastatin. The results could be regarded as a particular case to the reported SARs of statins up to now.

引用

页码：884 / 888

页数：5

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