Synthesis, Crystal Structure and Biological Evaluation of 4, 5, 6, 7-tetrahydropravastatin as HMG-CoA Reductase Inhibitor

被引：1
|
作者：
Li, Jing [1 ]
Li, Huan [1 ]
Zhang, Lei [1 ]
机构：
[1] S China Univ Technol, Sch Biosci & Bioengn, Guangzhou Higher Educ Mega Ctr, Guangzhou 510006, Guangdong, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2011年 / 8卷 / 09期
关键词：
Crystal structure; HMG-CoA reductase; hydrogenation; pravastatin; 4; 5; 6; 7-tetrahydropravastatin; COENZYME-A REDUCTASE; THERAPY;
D O I：
10.2174/157018011797200876
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
4, 5, 6, 7-Tetrahydropravastatin and its sodium salt as the hydrogenated derivatives of pravastatin were evaluated as HMG-CoA reductase inhibitor in vitro and in vivo, and they exhibited similar antihyperlipidaemic activity to pravastatin. The results could be regarded as a particular case to the reported SARs of statins up to now.
引用
收藏
页码：884 / 888
页数：5
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