Biotherapeutic Products, Cellular Factories, and Multiomics Integration in Metabolic Engineering

被引：1
|
作者：
Hoang Anh, Nguyen [1 ]
Min, Jung Eun [1 ]
Kim, Sun Jo [1 ]
Phuoc Long, Nguyen [2 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Seoul, South Korea
[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 08826, South Korea
来源：
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY | 2020年 / 24卷 / 11期
关键词：
biotherapeutics; metabolic engineering; metabolomics; multiomics; artificial intelligence; machine learning; ELECTROPHORESIS-MASS SPECTROMETRY; CAPILLARY-ELECTROPHORESIS; CE-MS; MONOCLONAL-ANTIBODIES; CHO-CELLS; FED-BATCH; THERAPEUTIC ANTIBODIES; SYSTEMATIC-APPROACH; CULTURE PROCESSES; NEXT-GENERATION;
D O I：
10.1089/omi.2020.0112
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Since the introduction of the first monoclonal antibody, biopharmaceuticals and biotherapeutic products manufactured in cellular factories are on the rise in modern medicine and therapeutics. Dynamic and real-time innovation strategies for operational implementation of biotherapeutic production are rapidly emerging. The advances in related fields such as genome editing technology, systems biology, and machine learning/artificial intelligence are expected to introduce innovative solutions in every aspect of the mammalian cell culture-based biotherapeutic production. This conceptual review offers a synthesis of the prospects and challenges of integration of multiomics technologies, and an integrative biology vision to cellular factories and biotherapeutic innovation.
引用
下载
收藏
页码：621 / 633
页数：13
相关论文
共 50 条
  • [1] Metabolic and cellular engineering for the production of natural products
    Yang, Dongsoo
    Eun, Hyunmin
    Prabowo, Cindy Pricilia Surya
    Cho, Sumin
    Lee, Sang Yup
    CURRENT OPINION IN BIOTECHNOLOGY, 2022, 77
  • [2] Metabolic and cellular engineering for the production of natural products
    Yang, Dongsoo
    Eun, Hyunmin
    Prabowo, Cindy Pricilia Surya
    Cho, Sumin
    Lee, Sang Yup
    Current Opinion in Biotechnology, 2022, 77
  • [3] Engineering microbial cell factories: Metabolic engineering of Corynebacterium glutamicum with a focus on non-natural products
    Heider, Sabine A. E.
    Wendisch, Volker F.
    BIOTECHNOLOGY JOURNAL, 2015, 10 (08) : 1170 - 1184
  • [4] Microalgae as versatile cellular factories for valued products
    Koller, Martin
    Muhr, Alexander
    Braunegg, Gerhart
    ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2014, 6 : 52 - 63
  • [5] Factories of the future? Metabolic engineering in plant cells
    Taylor, CB
    PLANT CELL, 1998, 10 (05): : 642 - 644
  • [6] Engineering of cell factories for the production of natural products
    Weber, Tilmann
    NATURAL PRODUCT REPORTS, 2019, 36 (09) : 1231 - 1232
  • [7] Multiomics Data Collection, Visualization, and Utilization for Guiding Metabolic Engineering
    Roy, Somtirtha
    Radivojevic, Tijana
    Forrer, Mark
    Marti, Jose Manuel
    Jonnalagadda, Vamshi
    Backman, Tyler
    Morrell, William
    Plahar, Hector
    Kim, Joonhoon
    Hillson, Nathan
    Garcia Martin, Hector
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2021, 9
  • [8] Metabolic engineering of microbial cell factories for production of nutraceuticals
    Yuan, Shuo-Fu
    Alper, Hal S.
    MICROBIAL CELL FACTORIES, 2019, 18
  • [9] SYSTEMS BIOLOGY AND METABOLIC ENGINEERING OF ARTHROSPIRA CELL FACTORIES
    Klanchui, Amornpan
    Vorapreeda, Tayvich
    Vongsangnak, Wanwipa
    Khannapho, Chiraphan
    Cheevadhanarak, Supapon
    Meechai, Asawin
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2012, 3 (04):
  • [10] Multidimensional Metabolic Engineering for Constructing Efficient Cell Factories
    Liu, Jianhui
    Hou, Jin
    TRENDS IN BIOTECHNOLOGY, 2020, 38 (05) : 468 - 469
12345