History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease)

被引：33

作者：

Chany, Anne-Caroline ^{[1
]}

Tresse, Cedric ^{[1
]}

Casarotto, Virginie ^{[1
]}

Blanchard, Nicolas ^{[2
]}

机构：

[1] Univ Haute Alsace, Ecole Natl Super Chim & Mulhouse, Lab Chim Organ & Bioorgan, EA4566, F-68093 Mulhouse, France

[2] Univ Strasbourg, CNRS UMR 7509, Ecole Europeenne Chim Polymeres & Mat, Lab Chim Mol, F-67087 Strasbourg, France

来源：

NATURAL PRODUCT REPORTS | 2013年 / 30卷 / 12期

关键词：

MYCOLACTONE-PRODUCING MYCOBACTERIA; COMPLETE GENOME SEQUENCE; HOST IMMUNE-RESPONSE; LABORATORY DIAGNOSIS; NATURAL-PRODUCTS; KETOREDUCTASE DOMAINS; REDUCTIVE EVOLUTION; HUMAN KERATINOCYTES; CLINICAL-EFFICACY; PERIPHERAL-BLOOD;

D O I：

10.1039/c3np70068b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mycobacterium ulcerans infections (Buruli ulcer disease) have a long history that can be traced back 150 years. The successive discoveries of the mycobacteria in 1948 and of mycolactone A/B in 1999, the toxin responsible for this dramatic necrotic skin disease, resulted in a paradigm shift concerning the disease itself and in a broader sense, delineated an entirely new role for bioactive polyketides as virulence factors. The fascinating history, biology and chemistry of M. ulcerans infections are discussed in this review.

引用

页码：1527 / 1567

页数：41

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