Multifunctionalized Sequence-Defined Oligomers from a Single Building Block

被引：183
|
作者：
Espeel, Pieter [1 ]
Carrette, Lieselot L. G. [2 ]
Bury, Katarzyna [1 ]
Capenberghs, Sven [1 ]
Martins, Jose C. [3 ]
Du Prez, Filip E. [1 ]
Madder, Annemieke [2 ]
机构：
[1] Univ Ghent, Dept Organ Chem, Polymer Chem Res Grp, B-9000 Ghent, Belgium
[2] Univ Ghent, Dept Organ Chem, Organ & Biomimet Chem Res Grp, B-9000 Ghent, Belgium
[3] Univ Ghent, Dept Organ Chem, NMR & Struct Anal Res Grp, B-9000 Ghent, Belgium
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 50期
关键词：
chemoselectivity; sequence-defined oligomers; solid-phase synthesis; synthetic methods; thiolactone; PHASE PEPTIDE-SYNTHESIS; PRECISION POLYMERS; SYNTHETIC-POLYMERS; ONE-POT; POLYMERIZATION; MONOMER; COVALENT; AMINE; CLICK; THIOL;
D O I：
10.1002/anie.201307439
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Another link in the chain: A thiolactone-based approach for the preparation of multifunctionalized sequence-defined oligomeric structures on solid support was established. The iterative aminolysis/chain extension method with a single building block and a variety of commercial amines allowed for the protecting group free synthesis of various oligomeric motifs with a unique backbone and a preprogrammed organization of side chain functionalities. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：13261 / 13264
页数：4
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