TGF-beta1 on osteoimmunology and the bone component cells

被引：92
|
作者：
Kasagi, Shimpei [1 ]
Chen, Wanjun [1 ]
机构：
[1] NIDCR, Mucosal Immunol Sect, NIH, Bethesda, MD 20892 USA
来源：
CELL AND BIOSCIENCE | 2013年 / 3卷
关键词：
GROWTH-FACTOR-BETA; MESENCHYMAL STEM-CELLS; TUMOR-NECROSIS-FACTOR; TGF-BETA; TRANSFORMING GROWTH-FACTOR-BETA-1; RHEUMATOID-ARTHRITIS; CROSS-TALK; 1,25-DIHYDROXYVITAMIN D-3; MORPHOGENETIC PROTEIN-2; PARATHYROID-HORMONE;
D O I：
10.1186/2045-3701-3-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TGF-beta 1 is an immunoregulatory cytokine that regulates immune cell proliferation, survival, differentiation, and migration. Compelling evidence has demonstrated a strong association between the immune and skeletal systems (so called Osteoimmunology), such as the critical role of TGF-beta 1 in the development and maintenance of the skeletal tissue. This review provides an overview of the mechanisms in which TGF-beta 1 interacts with bone component cells, such as osteoblasts, osteoclasts, chondrocytes, mesenchymal stem cells, and hematopoietic stem cells, in concert with other cytokines and hormones.
引用
收藏
页数：7
相关论文
共 50 条
  • [21] Autophagy Regulates Tgf-Beta1 Induced Fibrosis In Human Airway Smooth Muscle Cells
    Ghavami, S.
    Yeganeh, B.
    Serebrin, A.
    Mutawe, M. M.
    Sharma, P.
    McNeill, K. D.
    Stelmack, G.
    Kashani, H.
    Dixon, I. M.
    Klonisch, T.
    Nachtigal, M. W.
    Halayko, A. J.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183
  • [22] Gene polymorphisms within the coding region of TGF-beta1 affect cellular synthesis, secretion and processing of TGF-beta1 via the latent TGF-beta binding protein-1 (LTBP-1)
    Weiskirchen, R.
    Mohren, S.
    Weiskirchen, S.
    Gressner, A. M.
    JOURNAL OF HEPATOLOGY, 2008, 48 : S22 - S22
  • [23] The miRNA-mRNA Interactome of human trabecular meshwork cells treated with TGF-beta1
    Roodnat, Anton
    Callaghan, Breedge
    Doyle, Chelsey
    Atkinson, Sarah
    Willoughby, Colin
    ACTA OPHTHALMOLOGICA, 2024, 102
  • [24] ALPORT SYNDROME: THE EFFECTS OF SPIRONOLACTONE ON PROTEINURIA AND URINARY TGF-beta1
    Mastrangelo, Antonio
    Giani, Marisa
    Villa, Roberta
    Turolo, Stefano
    Marra, Giuseppina
    Tirelli, Amedea Silvia
    Hopfer, Helmut
    Edefonti, Alberto
    PEDIATRIC NEPHROLOGY, 2013, 28 (08) : 1547 - 1547
  • [25] Ligamentum flavum hypertrophy in lomber spinal stenozis and TGF-beta1
    Gokpinar, D.
    Yaycioglu, S.
    Yenisey, C.
    Yilmaz, M.
    FEBS JOURNAL, 2006, 273 : 162 - 162
  • [26] Endogenous TGF-beta1 Mediated Osteogenic Impairment of Medullar Mesenchymal Stromal Cells in Primary Myelofibrosis
    Martinaud, Christophe
    Desterke, Christophe
    Konopacki, Johanna
    Pieri, Lisa
    Golub, Rachel
    Schmutz, Sandrine
    Anginot, Adrienne
    Guerton, Bernadette
    Rochet, Nathalie
    Albanese, Patricia
    Henault, Emilie
    De Revel, Thierry
    Bourgeade, Marie-Francoise
    Alessandro, Vanucchi
    Lataillade, Jean-Jacques
    Le Bousse-Kerdiles, Marie-Caroline
    BLOOD, 2014, 124 (21)
  • [27] Upright posture promotes bone formation of rat lumbar vertebrae by up-regulate TGF-beta1
    Bian Qin
    Liang Qian-Qian
    Hou Wei
    Li Chen-Guang
    Shi Qi
    BONE, 2008, 43 : S93 - S93
  • [28] TGF-beta1 polymorphism is associated with the severity of rheumatoid arthritis.
    Kang, YM
    Han, SW
    Kim, GW
    Kim, SJ
    Lee, J
    Kim, SY
    ARTHRITIS AND RHEUMATISM, 2003, 48 (09): : S143 - S143
  • [29] MICE OVEREXPRESSING TGF-BETA1 ARE PROTECTED AGAINST CRESCENTIC GLOMERULONEPHRITIS
    Huang, X. R.
    Chung, A. C. K.
    Zhou, L.
    Li, A. G.
    Wang, X. J.
    Lan, H. Y.
    NEPHROLOGY, 2007, 12 : A12 - A13
  • [30] Inhibition of skeletal muscle fibrosis by neutralizing TGF-beta1 production
    Li, Y
    Foster, W
    Chan, YS
    Horaguchi, T
    Badlani, N
    Huard, J
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2002, 199 : S30 - S30
12345