Evidence for the formation and structure of palladacycles during Pd-catalyzed C-N bond formation with catalysts derived from bulky monophosphinobiaryl ligands

被引：72

作者：

Strieter, ER ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 06期

关键词：

aminations; cross-coupling; palladium; phosphanes;

D O I：

10.1002/anie.200502927

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The structural origins of the differences in catalytic activity observed between catalysts containing 2′-substituted and 2′,6′-disubstituted biaryl monophosphane ligands for a Pd-catalyzed C-N bond-forming reaction are discussed. It is shown that palladacycle formation is avoided and optimal catalyst activity is achieved through the use of the 2′,6′-disubstituted ligands. (tAm = tert-amyl, dppe = 1,2-bis(diphenylphosphanyl)-ethane). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：925 / 928

页数：4

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