Marine Natural Products and Other Derivatives as Potent Indoleamine 2,3-Dioxygenase Inhibitors

被引：16

作者：

Delfourne, Evelyne ^{[1
]}

机构：

[1] Univ Paul Sabatier, UMR CNRS 5068, Lab Synth & Physicochim Mol Interet Biol, F-31062 Toulouse 9, France

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2012年 / 12卷 / 10期

关键词：

Indoleamine 2,3-dioxygenase; IDO inhibitors; marine natural compounds; COMPETITIVE INHIBITORS; IMMUNE ESCAPE; EXIGUAMINE-A; TRYPTOPHAN; BINDING; TARGET; IDO; MECHANISM; CANCER;

D O I：

10.2174/138955712802762374

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cancer cells are able to elaborate enzymatic mechanisms allowing tumors to resist or escape imune rejection. Among the enzymes involved, indoleamine 2,3-dioxygenase (IDO), an intracellular enzyme that initiates the first and rate-limiting step of tryptophan breakdown along the kynurenine pathway, has emerged as a promising molecular target for the development of new immunotherapeutic anticancer agents. This review summarizes the synthesis and IDO activities of the different classes of marine and other inhibitors reported so far.

引用

页码：988 / 996

页数：9

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