Highly conserved antigenic epitope regions of hemagglutinin and neuraminidase genes between 2009 H1N1 and seasonal H1N1 influenza: vaccine considerations

被引：10
|
作者：
Huang, Ping [1 ,3 ]
Yu, Shouyi [2 ]
Wu, Changyou [4 ]
Liang, Lijun [1 ,3 ]
机构：
[1] Guangdong Prov Ctr Dis Control & Prevent, Key Lab Emergency Pathogen Detect, Guangzhou 511430, Guangdong, Peoples R China
[2] Southern Med Univ, Dept Epidemiol, Sch Publ Hlth & Trop Med, Guangzhou 510515, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Dept Epidemiol, Sch Publ Hlth, Guangzhou 510080, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Inst Immunol, Zhongshan Sch Med, Guangzhou 510080, Guangdong, Peoples R China
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2013年 / 11卷
基金：
中国国家自然科学基金;
关键词：
Influenza; H1N1; Epitope; Vaccine; Immunoinformatic; VIRUSES; PROTECTION; EMERGENCE; IMMUNITY;
D O I：
10.1186/1479-5876-11-47
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
An immunoinformatics study was conducted to determine the highly conserved antigenic epitope regions of hemagglutinin (HA) and neuraminidase (NA) genes in the humoral immunity and CD4+ and CD8+ T cellular immunity between 2009 pandemic H1N1 (pH1N1) and seasonal H1N1 (sH1N1) viruses. It was found that in sH1N1 viruses, 29 epitope regions of HA genes and 8 epitope regions of NA genes which had been experimentally identified, were highly conserved (97.1-100.0%) in the corresponding genes and predictive epitopes of the pH1N1 viruses. The results suggested that highly conserved antigenic epitope regions might act as the basis of common antigenic vaccines against pH1N1 and sH1N1 viruses.
引用
收藏
页数：8
相关论文
共 50 条
  • [31] Functional Balance of the Hemagglutinin and Neuraminidase Activities Accompanies the Emergence of the 2009 H1N1 Influenza Pandemic
    Xu, Rui
    Zhu, Xueyong
    McBride, Ryan
    Nycholat, Corwin M.
    Yu, Wenli
    Paulson, James C.
    Wilson, Ian A.
    JOURNAL OF VIROLOGY, 2012, 86 (17) : 9221 - 9232
  • [32] Molecular and genetic characteristics of hemagglutinin and neuraminidase in Iranian 2009 pandemic influenza A(H1N1) viruses
    Jandaghi, Nazanin Zahra Shafiei
    Azad, Talat Mokhtari
    Naseri, Maryam
    Yavarian, Jila
    Nategh, Rakhshandeh
    ARCHIVES OF VIROLOGY, 2010, 155 (05) : 717 - 721
  • [33] Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase
    Vavricka, Christopher John
    Liu Yue
    Li Qing
    Shi Yi
    Wu Yan
    Sun YePing
    Qi JianXun
    Gao, George Fu
    CHINESE SCIENCE BULLETIN, 2011, 56 (17): : 1747 - 1752
  • [34] Molecular and genetic characteristics of hemagglutinin and neuraminidase in Iranian 2009 pandemic influenza A(H1N1) viruses
    Nazanin Zahra Shafiei Jandaghi
    Talat Mokhtari Azad
    Maryam Naseri
    Jila Yavarian
    Rakhshandeh Nategh
    Archives of Virology, 2010, 155 : 717 - 721
  • [35] Receptor recognition mechanism of human influenza A H1N1 (1918), avian influenza A H5N1 (2004), and pandemic H1N1 (2009) neuraminidase
    Jongkon, Nipa
    Sangma, Chak
    JOURNAL OF MOLECULAR MODELING, 2012, 18 (01) : 285 - 293
  • [36] 2009 Influenza A (H1N1) Pandemic
    Kumate Rodriguez, Jesus
    CIRUGIA Y CIRUJANOS, 2009, 77 (03): : 157 - 158
  • [37] Pandemic: 2009 Influenza A (H1N1)
    Shulman, Stanford T.
    PEDIATRIC ANNALS, 2009, 38 (12): : 635 - 636
  • [38] 2009 pandemic influenza A(H1N1)
    Cazzadori, Angelo
    Conti, Michela
    Concia, Ercote
    MULTIDISCIPLINARY RESPIRATORY MEDICINE, 2009, 4 (06): : 401 - 402
  • [39] 2009 H1N1 Influenza Pandemic
    Woo, Teri Moser
    JOURNAL OF PEDIATRIC HEALTH CARE, 2010, 24 (04) : 258 - 266
  • [40] Identification of Seasonal Vaccine Hemagglutinin Subtype 1 (H1) Epitopes in Mexican Isolates of the New Influenza A (H1N1) 2009 Virus
    Rodriguez-Alvarez, Mauricio
    Maria Velasco-Velasco, Ana
    Alvarez-Anell, Nelson J.
    Eugenia Jimenez-Corona, Maria
    Ponce de Leon-Rosales, Samuel
    ARCHIVES OF MEDICAL RESEARCH, 2009, 40 (08) : 687 - 692
12345