Highly conserved antigenic epitope regions of hemagglutinin and neuraminidase genes between 2009 H1N1 and seasonal H1N1 influenza: vaccine considerations

被引：10
|
作者：
Huang, Ping [1 ,3 ]
Yu, Shouyi [2 ]
Wu, Changyou [4 ]
Liang, Lijun [1 ,3 ]
机构：
[1] Guangdong Prov Ctr Dis Control & Prevent, Key Lab Emergency Pathogen Detect, Guangzhou 511430, Guangdong, Peoples R China
[2] Southern Med Univ, Dept Epidemiol, Sch Publ Hlth & Trop Med, Guangzhou 510515, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Dept Epidemiol, Sch Publ Hlth, Guangzhou 510080, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Inst Immunol, Zhongshan Sch Med, Guangzhou 510080, Guangdong, Peoples R China
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2013年 / 11卷
基金：
中国国家自然科学基金;
关键词：
Influenza; H1N1; Epitope; Vaccine; Immunoinformatic; VIRUSES; PROTECTION; EMERGENCE; IMMUNITY;
D O I：
10.1186/1479-5876-11-47
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
An immunoinformatics study was conducted to determine the highly conserved antigenic epitope regions of hemagglutinin (HA) and neuraminidase (NA) genes in the humoral immunity and CD4+ and CD8+ T cellular immunity between 2009 pandemic H1N1 (pH1N1) and seasonal H1N1 (sH1N1) viruses. It was found that in sH1N1 viruses, 29 epitope regions of HA genes and 8 epitope regions of NA genes which had been experimentally identified, were highly conserved (97.1-100.0%) in the corresponding genes and predictive epitopes of the pH1N1 viruses. The results suggested that highly conserved antigenic epitope regions might act as the basis of common antigenic vaccines against pH1N1 and sH1N1 viruses.
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页数：8
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