Pathophysiologic mechanisms of chronic rhinosinusitis

Rhinosinusitis is one of the most common disorders and is a major health problem worldwide. This multifactorial disease has a complex nature, and the limited understanding of its relationship with associated factors makes it difficult to precisely define and classify. Broadly speaking, rhinosinusitis may be defined clinically as a condition manifested by an inflammatory response involving the mucous membranes of the nasal cavity and paranasal sinuses. Because of the heterogeneous nature of chronic rhinosinusitis, further studies are essential to a good understanding of the mechanisms that cause this pathology.