Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae)

被引：17

作者：

Mukhtar, Mat Ropi ^{[1
]}

Osman, Norfaizah ^{[1
]}

Awang, Khalijah ^{[1
]}

Hazni, Hazrina ^{[1
]}

Qureshi, Ahmad Kaleem ^{[1
]}

Hadi, A. Hamid A. ^{[1
]}

Zaima, Kazuma ^{[2
]}

Morita, Hiroshi ^{[2
]}

Litaudon, Marc ^{[3
]}

机构：

[1] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 50603, Malaysia

[2] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

[3] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

MOLECULES | 2012年 / 17卷 / 01期

关键词：

Ochreinauclea maingayii; neonaucline; nauledine; cadamine; Rubiaceae; alkaloid; NAUCLEA-DIDERRICHII; PYRIDINE ALKALOIDS; CONSTITUENTS; BISBENZYLISOQUINOLINE; UNCARIA;

D O I：

10.3390/molecules17010267

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new indole alkaloid; neonaucline (1), along with six known compounds-Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A-were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, C-13-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1-3 after injection of each sample at 1 x 10(-5) M.

引用

页码：267 / 274

页数：8