PTPN22 splice forms: a new role in rheumatoid arthritis

被引：11
|
作者：
Diaz-Gallo, Lina-Marcela [1 ]
Martin, Javier [1 ]
机构：
[1] CSIC, IPBLN, Granada 18100, Spain
来源：
GENOME MEDICINE | 2012年 / 4卷
关键词：
Protein tyrosine phosphatase non-receptor type 22 (PTPN22); autoimmune diseases; rheumatoid arthritis; splice forms; VARIANT;
D O I：
10.1186/gm312
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Genetic variation in the protein tyrosine phosphatase non-receptor type gene 22 (PTPN22, encoding lymphoid tyrosine phosphatase, LYP) influences the risk of developing multiple autoimmune diseases, but the underlying mechanisms are not completely understood. In a recent study published in Genome Medicine, Ronninger et al. showed that there are differences in the expression of PTPN22 isoforms between peripheral blood mononuclear cells from rheumatoid arthritis patients and those of healthy controls. This study provides new insights into the role of PTPN22 in autoimmune diseases.
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页数：4
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