Discovery of the novel HLA-DRB1*03:77 allele in a Taiwanese unrelated hematopoietic stem cell donor by a sequence-based typing method and identification of the probable HLA haplotype in association with DRB1*03:77

被引：18
|
作者：
Yang, K. L. [1 ,2 ,3 ,4 ]
Lee, S. K. [1 ,2 ,3 ]
Kao, R. H. [1 ,2 ,3 ]
Lin, C. L. [1 ,2 ,3 ]
Lin, P. Y. [1 ,2 ,3 ]
机构：
[1] Buddhist Tzu Chi Gen Hosp, Immunogenet Lab, Buddhist Compass Relief Tzu Chi Fdn, Hualien 970, Taiwan
[2] Buddhist Tzu Chi Gen Hosp, Cord Blood Bank, Buddhist Compass Relief Tzu Chi Fdn, Buddhist Tzu Chi Stem Cells Ctr, Hualien 970, Taiwan
[3] Buddhist Tzu Chi Gen Hosp, Marrow Donor Registry, Buddhist Compass Relief Tzu Chi Fdn, Hualien 970, Taiwan
[4] Buddhist Tzu Chi Univ, Dept Med Biotechnol, Buddhist Compass Relief Tzu Chi Fdn, Hualien, Taiwan
来源：
INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2012年 / 39卷 / 05期
关键词：
LEUKOCYTE ANTIGEN-A; MARROW DONOR; DIVERSITY; POPULATION;
D O I：
10.1111/j.1744-313X.2012.01110.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Here, we report a novel human leucocyte antigen (HLA)-DRB1 allele, DRB1*03:77, discovered in a Taiwanese unrelated volunteer hematopoietic stem cell donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*03:77 is identical to the DNA sequence of DRB1*03:01:01 in exon 2 except one nucleotide at position 223 (G?C). The nucleotide substitution caused an amino acid replacement at residue 46 (E?Q). The formation of DRB1*03:77 was thought as the result of a nucleotide point mutation. The probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*03:77 may be deduced as A*33-B*58-DRB1*03:77. The donor was a Minna Taiwanese whose ancestors came from mainland China.
引用
收藏
页码：442 / 444
页数：3
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