Risk of breast cancer related to pregnancy

被引：5

作者：

Lesieur, B. ^{[1
]}

Vercambre, M. ^{[1
]}

Dubernard, G. ^{[1
,2
]}

Khosrotehrani, K. ^{[1
,3
]}

Uzan, S. ^{[1
,2
]}

Aractingi, S. ^{[1
,3
]}

Rouzier, R. ^{[1
,2
]}

机构：

[1] Univ Paris 06, Fac Med St Antoine, UPRES 4053, F-75012 Paris, France

[2] Hop Tenon, Serv Gynecol Obstet & Med Reprod, F-75020 Paris, France

[3] Hop Tenon, Serv Dermatol, F-75020 Paris, France

来源：

JOURNAL DE GYNECOLOGIE OBSTETRIQUE ET BIOLOGIE DE LA REPRODUCTION | 2008年 / 37卷 / 01期

关键词：

Cancer; Breast; Pregnancy; Microchimerism; Oncogenesis;

D O I：

10.1016/j.jgyn.2007.10.004

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

After a pregnancy, there is a transitory increase in the risk of breast cancer. During the pregnancy, the number of mammary epithelial. cells increases massively. This increase seems partly due to the expansion of stem cells and proliferating intermediate cells. This proliferation of epithelial cells is accompanied by angiogenesis and by recruitment of stromal cells, as well as changes of the extracellular matrix. During any pregnancy, there is cell trafficking between mother and foetus. Hematopoietic or mesenchymal foetal stem cells are transferred in maternal circulation and could be used by the tumor as support cells and take part in the tumoral development. The study of the mechanisms of this specific oncogenesis may help to develop chemoprevention strategies. (c) 2007 Elsevier Masson SAS. Tous droits reserves.

引用

页码：77 / 81

页数：5

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