Invasive pulmonary aspergillosis diagnosed early by polymerase chain reaction assay

被引：8

作者：

Kawamura, S ^{[1
]}

Maesaki, S ^{[1
]}

Omagari, K ^{[1
]}

Hashiguchi, K ^{[1
]}

Tomono, K ^{[1
]}

Tashiro, T ^{[1
]}

Kohno, S ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 8528501, Japan

来源：

INTERNAL MEDICINE | 1999年 / 38卷 / 09期

关键词：

serodiagnosis; Aspergillus fumigatus; enzyme-linked immunosorbent assay (ELISA); galactomannan; prednizolone;

D O I：

10.2169/internalmedicine.38.744

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We compared the usefulness of a polymerase chain reaction (PCR) assay for the early diagnosis of invasive pulmonary aspergillosis with the serodiagnosis of sufficient concentrations of galactomannan using the same serum samples. A patient was treated with prednisolone for the management of hepatitis. Computed tomography (CT) scan of the chest showed the nodular shadow with a cavity containing a clear fungus ball. DNA of Aspergillus spp. from a serum sample was detected and using the same serum sample, both latex agglutination and sandwich enzyme-linked immunosorbent assay (ELISA) of galactomannan were negative. PCR assay provides an early diagnosis of invasive pulmonary aspergillosis compared with ELISA of galactomannan.

引用

页码：744 / 746

页数：3

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