Synthesis of some new 2,6-disubstituted-3(2H)-pyridazinone derivatives and investigation of their analgesic, anti-inflammatory and antimicrobial activities

被引：23
|
作者：
Tiryaki, Didem [1 ]
Sukuroglu, Murat [1 ]
Dogruer, Deniz S. [1 ]
Akkol, Esra [2 ]
Ozgen, Selda [3 ]
Sahin, M. Fethi [1 ]
机构：
[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06330 Ankara, Turkey
[2] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey
[3] Gazi Univ, Fac Pharm, Dept Microbiol, TR-06330 Ankara, Turkey
来源：
MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 06期
关键词：
3(2H)-pyridazinone; Analgesic activity; Anti-inflammatory activity; Antimicrobial activity; INHIBITORS;
D O I：
10.1007/s00044-012-0253-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this study, 12 new 3(2H)-pyridazinone derivatives carrying 4-substituted phenylpiperazinylethyl moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by H-1-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound 9c showed the best analgesic and anti-inflammatory activities without causing any gastric effect in stomachs of tested animals. In addition, the synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains.
引用
收藏
页码：2553 / 2560
页数：8
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