An alternative representation of Fractal Gene Regulatory Networks facilitating analysis and interpretation

被引:0
|
作者
Zahadat, Payam [1 ,2 ]
Stoy, Kasper [1 ]
机构
[1] Univ So Denmark, Odense, Denmark
[2] Shiraz Univ, Shiraz, Iran
关键词
Gene regulatory networks; Evolutionary computation; Network representation; Modular robots; LOCOMOTION; DYNAMICS; DESIGN; GENOME; ROBOT;
D O I
10.1007/s10472-012-9305-y
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
This paper introduces a new representation of Fractal Gene Regulatory Networks (FGRNs) that facilitates analysis and interpretation of their internal mechanisms. FGRNs are demonstrated to be useful tools in solving some problems but because of the complex nature of using the fractal proteins, an FGRN solution is difficult to analyze hindering an understanding of its functionality. The new representation uses a mathematical network-oriented perspective and clarifies the role of fractals in the running FGRNs. The underlying network structure and the transfer functions of the nodes are derived from the model and make reductions in the computational costs of the solutions. As a case study, FGRNs are evolved as distributed controllers based on sensor information for a modular snake robot and the solutions are analyzed and interpreted using the proposed network-oriented representation. The analysis reveals that the underlying control strategy is a simple linear equation where the modules have the access to the proper sensors. The more complex solutions are generated by the evolved FGRN controllers where the access of the modules to the sensory information is more restricted. The underlying effective parts of the networks are demonstrated and analyzed for the controllers in the both cases.
引用
收藏
页码:285 / 316
页数:32
相关论文
共 50 条
  • [41] Single-cell transcriptomic analysis reveals dynamic alternative splicing and gene regulatory networks among pancreatic islets
    Yunjin Li
    Jiwei Chen
    Qiyue Xu
    Zebei Han
    Fei Tan
    Tieliu Shi
    Geng Chen
    Science China(Life Sciences) , 2021, (01) : 174 - 176
  • [42] Single-cell transcriptomic analysis reveals dynamic alternative splicing and gene regulatory networks among pancreatic islets
    Yunjin Li
    Jiwei Chen
    Qiyue Xu
    Zebei Han
    Fei Tan
    Tieliu Shi
    Geng Chen
    Science China Life Sciences, 2021, 64 : 174 - 176
  • [43] Gene Expression Is Not Random: Scaling, Long-Range Cross-Dependence, and Fractal Characteristics of Gene Regulatory Networks
    Ghorbani, Mahboobeh
    Jonckheere, Edmond A.
    Bogdan, Paul
    FRONTIERS IN PHYSIOLOGY, 2018, 9
  • [44] Encoding Threshold Boolean Networks into Reaction Systems for the Analysis of Gene Regulatory Networks
    Barbuti, Roberto
    Bove, Pasquale
    Gori, Roberta
    Gruska, Damas
    Levi, Francesca
    Milazzo, Paolo
    FUNDAMENTA INFORMATICAE, 2021, 179 (02) : 205 - 225
  • [45] Hierarchical analysis of piecewise affine models of gene regulatory networks
    Tournier, Laurent
    Gouze, Jean-Luc
    THEORY IN BIOSCIENCES, 2008, 127 (02) : 125 - 134
  • [46] Limit Cycle Analysis of a Class of Hybrid Gene Regulatory Networks
    Sun, Honglu
    Folschette, Maxime
    Magnin, Morgan
    COMPUTATIONAL METHODS IN SYSTEMS BIOLOGY, CMSB 2022, 2022, 13447 : 217 - 236
  • [47] The analysis of Gene Regulatory Networks in plant evo-devo
    Vialette-Guiraud, Aurelie C. M.
    Andres-Robin, Amelie
    Chambrier, Pierre
    Tavares, Raquel
    Scutt, Charles P.
    JOURNAL OF EXPERIMENTAL BOTANY, 2016, 67 (09) : 2549 - 2563
  • [48] Stochastic analysis of gene regulatory networks using moment closure
    Singh, Abhyudai
    Hespanha, Joao Pedro
    2007 AMERICAN CONTROL CONFERENCE, VOLS 1-13, 2007, : 2800 - 2805
  • [49] Hierarchical analysis of piecewise affine models of gene regulatory networks
    Laurent Tournier
    Jean-Luc Gouzé
    Theory in Biosciences, 2008, 127 : 125 - 134
  • [50] A GENERAL FRAMEWORK FOR STABILITY ANALYSIS OF GENE REGULATORY NETWORKS WITH DELAY
    Shlykova, Irina
    Ponosov, Arcady
    Nepomnyashchikh, Yury
    Shindiapin, Andrei
    ELECTRONIC JOURNAL OF DIFFERENTIAL EQUATIONS, 2008,