Synthesis, Spectral Studies and in vitro Antibacterial Evaluation of Triaza and Dioxa Aza Spiro Derivatives

被引：0

作者：

Natarajan, Manivannan ^{[1
]}

Balachandravinayagam, Elanchezhian ^{[1
]}

Selvaraju, Meenakshi ^{[2
]}

Ganesan, Selvanathan ^{[1
]}

机构：

[1] AVC Coll Autonomous, Dept Chem, Mannampandal 609305, Mayiladuthurai, India

[2] Annamalai Univ, CAS Marine Biol, Parangipettai 608205, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 01期

关键词：

Triaza; Dioxa aza; Spiro; Chair conformation; Antibacterial; CONFORMATIONAL-ANALYSIS; C-13; NMR;

D O I：

10.14233/ajchem.2013.12976

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Six compounds 7,9-diphenyl-1,4-dioxa-8-azaspiro[4.5]decane 1-6 have been synthesized by Mannich reaction and cyclo condensation. The structures and stereochemistry established by IR, NMR studies. The purities were checked by elemental analysis. The synthesized compounds 1-6 adopt chair conformation with equatorial orientation of the aryl groups. All the compounds were screened for their antibacterial activity against Proteus mirabilis, Klebsiella oxytoca, Staphylococcus aureus and Salmonella paratyphi. The compound 5 exhibited excellent in vitro antibacterial activity in all species.

引用

页码：277 / 281

页数：5

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