Synthesis, Spectral Studies and in vitro Antibacterial Evaluation of Triaza and Dioxa Aza Spiro Derivatives

被引：0

作者：

Natarajan, Manivannan ^{[1
]}

Balachandravinayagam, Elanchezhian ^{[1
]}

Selvaraju, Meenakshi ^{[2
]}

Ganesan, Selvanathan ^{[1
]}

机构：

[1] AVC Coll Autonomous, Dept Chem, Mannampandal 609305, Mayiladuthurai, India

[2] Annamalai Univ, CAS Marine Biol, Parangipettai 608205, India

来源：

ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 01期

关键词：

Triaza; Dioxa aza; Spiro; Chair conformation; Antibacterial; CONFORMATIONAL-ANALYSIS; C-13; NMR;

D O I：

10.14233/ajchem.2013.12976

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Six compounds 7,9-diphenyl-1,4-dioxa-8-azaspiro[4.5]decane 1-6 have been synthesized by Mannich reaction and cyclo condensation. The structures and stereochemistry established by IR, NMR studies. The purities were checked by elemental analysis. The synthesized compounds 1-6 adopt chair conformation with equatorial orientation of the aryl groups. All the compounds were screened for their antibacterial activity against Proteus mirabilis, Klebsiella oxytoca, Staphylococcus aureus and Salmonella paratyphi. The compound 5 exhibited excellent in vitro antibacterial activity in all species.

引用

页码：277 / 281

页数：5

共 50 条

[1] Synthesis, Characterization and in vitro Antibacterial Evaluation of New Oxindoles and Spiro-Oxindoles Derivatives
Hassan, Mohamed, I
Hassane, Abdallah M. A.
EGYPTIAN JOURNAL OF CHEMISTRY, 2019, 62 : 103 - 113
[2] Lipophilic quinolone derivatives: Synthesis and in vitro antibacterial evaluation
Sadowski, Elodie
Bercot, Beatrice
Chauffour, Aurelie
Gomez, Catherine
Varon, Emmanuelle
Mainardis, Mary
Sougakoff, Wladimir
Mayer, Claudine
Sachon, Emmanuelle
Anquetin, Guillaume
Aubry, Alexandra
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 55
[3] Synthesis, spectral characterization, antibacterial, cytotoxic evaluation and docking studies of new urea and thiourea derivatives
Ramaswamy, Shanmugam
Kongara, Deepak
Priyanka, D. L.
Gade, Ramya
Raj, R. Krishna
Gayathri, R.
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 2022, 59 (07): : 767 - 776
[4] Synthesis and In Vitro Antibacterial Evaluation of Mannich Base Nitrothiazole Derivatives
Dube, Phelelisiwe S.
Hart, Dylan
Legoabe, Lesetja J.
Jordaan, Audrey
Warner, Digby F.
Beteck, Richard M.
MOLBANK, 2024, 2024 (01)
[5] Synthesis, Characterization, and in vitro Antibacterial Evaluation of Barbituric Acid Derivatives
S. Shukla
A. Bishnoi
P. Devi
S. Kumar
A. Srivastava
K. Srivastava
S. Fatma
Russian Journal of Organic Chemistry, 2019, 55 : 860 - 865
[6] Synthesis, Characterization, and in vitro Antibacterial Evaluation of Barbituric Acid Derivatives
Shukla, S.
Bishnoi, A.
Devi, P.
Kumar, S.
Srivastava, A.
Srivastava, K.
Fatma, S.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 55 (06) : 860 - 865
[7] Synthesis and spectral data of unknown lilolidine spiro derivatives
Palma, A
Silva, J
Stashenko, E
Martínez, JR
Kouznetsov, V
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1999, 36 (03) : 675 - 679
[8] SYNTHESIS, IN VITRO ANTIBACTERIAL ACTIVITY AND DOCKING STUDIES OF NEWER PYRAZOLE DERIVATIVES
Sthalam, Vinay Kumar
Bethanamudi, Prasanna
Gadidasu, Kranthi Kumar
Kumar, Thatipamula Ranjith
Velidandi, Amarnath
PHARMACOPHORE, 2015, 6 (04): : 196 - 204
[9] Synthesis and antibacterial activity of some fused and spiro imidazolidine derivatives
Pardasani, P
Pardasani, RT
Sherry, D
Chaturvedi, V
Saxena, A
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2000, 10 (02) : 129 - 134
[10] Synthesis and In Vitro Antibacterial Evaluation of Some Novel Annulated Quinazolinone Derivatives
A. I. El-Shenawy
Russian Journal of General Chemistry, 2018, 88 : 1712 - 1719

← 1 2 3 4 5 →