OATP1B1-MEDIATED HEPATIC UPTAKE OF SN-38, AN ACTIVE METABOLITE OF IRINOTECAN, AND ITS INHIBITION BY UREMIC TOXINS IN HUMANS

被引：0
|
作者：
Fujita, K. [1 ]
Sugiura, T. [2 ]
Okumura, H. [2 ]
Umeda, S. [2 ]
Nakamichi, N. [2 ]
Sasaki, Y. [1 ]
Kato, Y. [2 ]
机构：
[1] Saitama Med Univ, Hidaka, Japan
[2] Kanazawa Univ, Kanazawa, Ishikawa, Japan
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2013年 / 93卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：S32 / S32
页数：1
相关论文
共 50 条
  • [41] Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans
    Hirano, M
    Maeda, K
    Shitara, Y
    Sugiyama, Y
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 311 (01): : 139 - 146
  • [42] Transporter and metabolic enzyme-mediated intra-enteric circulation of SN-38, an active metabolite of irinotecan: A new concept
    Martha, Larasati
    Nakata, Akane
    Furuya, Shinnosuke
    Liu, Wangyang
    Zhang, Xieyi
    Mizoi, Kenta
    Ogihara, Takuo
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 665 : 19 - 25
  • [43] Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE
    Hosseini, Sabrina Khageh
    Kolterer, Stefanie
    Steiner, Marlene
    von Manstein, Viktoria
    Gerlach, Katharina
    Trojan, Joerg
    Waidmann, Oliver
    Zeuzem, Stefan
    Schulze, Joerg O.
    Hahn, Steffen
    Steinhilber, Dieter
    Gatterdam, Volker
    Tampe, Robert
    Biondi, Ricardo M.
    Proschak, Ewgenij
    Zoernig, Martin
    BIOCHEMICAL PHARMACOLOGY, 2017, 146 : 53 - 62
  • [44] EFFECT OF GENETIC POLYMORPHISM IN UDP-GLUCURONOSYLTRANSFERASE (UGT) 1A1 ON PHARMACOKINETICS (PK) OF IRINOTECAN AND ITS METABOLITES, SN-38 AND SN-38 GLUCURONIDE.
    Abdelrahman, R.
    Ahmed, M. A.
    Goetz, M. P.
    Buckner, J. C.
    Pitot, H. C.
    Erlichman, C.
    Jaeckle, K. A.
    Reid, J. M.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2017, 101 (S1) : S54 - S54
  • [45] SN-38, an active metabolite of irinotecan, enhances anti-PD-1 treatment efficacy in head and neck squamous cell carcinoma
    Lee, Yi-Mei
    Chen, Yu-Hsin
    Ou, Da-Liang
    Hsu, Chia-Lang
    Liu, Jia-Hua
    Ko, Jenq-Yuh
    Hu, Mickey C-T
    Tan, Ching-Ting
    JOURNAL OF PATHOLOGY, 2023, 259 (04): : 428 - 440
  • [46] Minimal contribution of the hepatic uptake transporter OATP1B1 to the inter-individual variability in SN-38 pharmacokinetics in cancer patients without severe renal failure
    Ayako Tsuboya
    Yutaro Kubota
    Hiroo Ishida
    Ryotaro Ohkuma
    Tomoyuki Ishiguro
    Yuya Hirasawa
    Hirotsugu Ariizumi
    Takuya Tsunoda
    Yasutsuna Sasaki
    Natsumi Matsumoto
    Yusuke Kondo
    Yukana Tomoda
    Hiroyuki Kusuhara
    Ken-ichi Fujita
    Cancer Chemotherapy and Pharmacology, 2021, 88 : 543 - 553
  • [47] Minimal contribution of the hepatic uptake transporter OATP1B1 to the inter-individual variability in SN-38 pharmacokinetics in cancer patients without severe renal failure
    Tsuboya, Ayako
    Kubota, Yutaro
    Ishida, Hiroo
    Ohkuma, Ryotaro
    Ishiguro, Tomoyuki
    Hirasawa, Yuya
    Ariizumi, Hirotsugu
    Tsunoda, Takuya
    Sasaki, Yasutsuna
    Matsumoto, Natsumi
    Kondo, Yusuke
    Tomoda, Yukana
    Kusuhara, Hiroyuki
    Fujita, Ken-ichi
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2021, 88 (03) : 543 - 553
  • [48] Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: In vitro evidence and effect of single nucleotide polymorphisms
    Nozawa, T
    Minami, H
    Sugiura, S
    Tsuji, A
    Tamai, I
    DRUG METABOLISM AND DISPOSITION, 2005, 33 (03) : 434 - 439
  • [49] Distribution and quantification of irinotecan and its active metabolite SN-38 in colon cancer murine model systems using MALDI MSI
    Buck, Achim
    Halbritter, Susanne
    Spaeth, Christoph
    Feuchtinger, Annette
    Aichler, Michaela
    Zitzelsberger, Horst
    Janssen, Klaus-Peter
    Walch, Axel
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2015, 407 (08) : 2107 - 2116
  • [50] Distribution and quantification of irinotecan and its active metabolite SN-38 in colon cancer murine model systems using MALDI MSI
    Achim Buck
    Susanne Halbritter
    Christoph Späth
    Annette Feuchtinger
    Michaela Aichler
    Horst Zitzelsberger
    Klaus-Peter Janssen
    Axel Walch
    Analytical and Bioanalytical Chemistry, 2015, 407 : 2107 - 2116
12345