(S)-Ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate

被引：0
|
作者：
Lentini, Giovanni [1 ]
Cavalluzzi, Maria Maddalena [1 ]
Degennaro, Leonardo [1 ]
Fracchiolla, Giuseppe [1 ]
Perna, Filippo [1 ]
Scilimati, Antonio [1 ]
机构：
[1] Univ Bari, Dept Pharm Pharmaceut Sci, Via E Orabona 4, I-70126 Bari, Italy
来源：
MOLBANK | 2019年 / 01期
关键词：
phenylalanine; l-DOPA; iodination; medicinal chemistry; FLUORINATION; F-18;
D O I：
10.3390/M1049
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A multistep gram-scale synthesis of (S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate (2) has been developed. The title compound was prepared starting from commercially available l-DOPA which was O- and N-protected before undergoing iodination by CF3CO2Ag/I-2. The structure of the target compound was confirmed using IR, H-1-NMR, C-13-NMR, 2D (COSY, HSQC) NMR spectroscopy, as well as ESI-MS and HRMS.
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页数：4
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