A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP

被引：156
|
作者：
Lauri, SE
Bortolotto, ZA
Bleakman, D
Ornstein, PL
Lodge, D
Isaac, JTR
Collingridge, GL [1 ]
机构：
[1] Univ Bristol, Sch Med, Dept Anat, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England
[2] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA
来源：
NEURON | 2001年 / 32卷 / 04期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
D O I：
10.1016/S0896-6273(01)00511-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The mechanisms involved in mossy fiber LTP in the hippocampus are not well established. In the present study, we show that the kainate receptor antagonist LY382884 (10 muM) is selective for presynaptic kainate receptors in the CA3 region of the hippocampus. At a concentration at which it blocks mossy fiber LTP, LY382884 selectively blocks the synaptic activation of a presynaptic kainate receptor that facilitates AMPA receptor-mediated synaptic transmission. Following the induction of mossy fiber LTP, there is a complete loss of the presynaptic kainate receptor-mediated facilitation of synaptic transmission. These results identify a central role for the presynaptic kainate receptor in the induction of mossy fiber LTP. In addition, these results suggest that the pathway by which kainate receptors facilitate glutamate release is utilized for the expression of mossy fiber LTP.
引用
收藏
页码：697 / 709
页数：13
相关论文
共 50 条
  • [31] Role of Kainate Autoreceptors in Short-Term Plasticity at Hippocampal Mossy Fiber Synapses
    Dargan, Sheila L.
    Amici, Mascia
    JOURNAL OF NEUROSCIENCE, 2009, 29 (18): : 5713 - 5715
  • [32] In the Developing Rat Hippocampus, Endogenous Activation of Presynaptic Kainate Receptors Reduces GABA Release from Mossy Fiber Terminals
    Caiati, Maddalena D.
    Sivakumaran, Sudhir
    Cherubini, Enrico
    JOURNAL OF NEUROSCIENCE, 2010, 30 (05): : 1750 - 1759
  • [33] Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP
    Contractor, A
    Rogers, C
    Maron, C
    Henkemeyer, M
    Swanson, GT
    Heinemann, SF
    SCIENCE, 2002, 296 (5574) : 1864 - 1869
  • [34] NMDA receptor-dependent LTP at the mossy fiber - Granule cell synapse of rat cerebellum
    DAngelo, E
    Rossi, P
    Armano, S
    Taglietti, V
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1997, 434 (03): : 45 - 45
  • [35] Kainate receptor-mediated presynaptic inhibition converges with presynaptic inhibition mediated by Group II mGluRs and long-term depression at the hippocampal mossy fiber-CA3 synapse
    Negrete-Diaz, J. V.
    Sihra, T. S.
    Delgado-Garcia, J. M.
    Rodriguez-Moreno, A.
    JOURNAL OF NEURAL TRANSMISSION, 2007, 114 (11) : 1425 - 1431
  • [36] Kainate receptor-mediated presynaptic inhibition converges with presynaptic inhibition mediated by Group II mGluRs and long-term depression at the hippocampal mossy fiber-CA3 synapse
    J. V. Negrete-Díaz
    T. S. Sihra
    J. M. Delgado-García
    A. Rodríguez-Moreno
    Journal of Neural Transmission, 2007, 114 : 1425 - 1431
  • [37] Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses.
    Lauri, SE
    Delany, C
    Clarke, VRJ
    Bortolotto, ZA
    Ornstein, PL
    Isaac, JTR
    Collingridge, GL
    NEUROPHARMACOLOGY, 2001, 41 (08) : 907 - 915
  • [38] Mossy fiber LTP induced by low-frequency stimulation
    Ito, Koichi
    Frausto, Shanti F.
    Marszalec, William
    Kaneda, Makoto
    Hashikawa, Tsutomu
    Swanson, Geoffrey T.
    NEUROSCIENCE RESEARCH, 2008, 61 : S80 - S80
  • [39] Activation of AMPA, kainate, and metabotropic receptors at hippocampal mossy fiber synapses: Role of glutamate diffusion
    Min, MY
    Rusakov, DA
    Kullmann, DM
    NEURON, 1998, 21 (03) : 561 - 570
  • [40] Mossy fibre sprouting: Evidence against a facilitatory role in epileptogenesis
    Elmer, E
    Kokaia, Z
    Kokaia, M
    Lindvall, O
    McIntyre, DC
    NEUROREPORT, 1997, 8 (05) : 1193 - 1196
12345