Expression of peroxisome proliferator-activated receptor (PPAR) family and survival analysis in patients with multiple myeloma using microarray gene expression profiles

Peroxisome proliferator activated receptor (PPAR) family consists of 3 members: alpha, gamma, and delta (beta). PPARs play essential roles in cellular differentiation, development, and metabolism. However, little is known about the impact of PPARs on myeloma progression. The aim of this study is to systematically investigate the expression and survival rate of PPARs in myeloma. Using the public available datasets downloaded from Gene Expression Omnibus (GEO), gene expression of PPARs in clinical samples from human bone marrow and myeloma was obtained. Meanwhile, the prognostic value of PPARs in the primary myeloma was assessed using the Arkansas and Mulligan myeloma microarray datasets. mRNA levels of PPARs have a relatively lower expression in myeloma compared to bone marrow cells. High expression of PPARs predicts a good prognostic value for the overall survival rate. In conclusion, in this study, we elaborate the role of PPARs in myeloma progression, which may provide useful clinical significance for target/ drug development for myeloma therapeutics.