ABO Blood Type Incompatible Kidney Transplantation Without Splenectomy Prepared With Plasma Exchange and Rituximab

被引：19
|
作者：
Chikaraishi, T. [1 ]
Sasaki, H. [1 ]
Tsutsumi, H. [1 ]
Miyano, S. [1 ]
Nakazawa, R. [1 ]
Nakano, T. [1 ]
Kitajima, K. [1 ]
Kudo, H. [1 ]
Takahashi, T. [1 ]
Sato, Y. [1 ]
Kimura, K. [1 ]
机构：
[1] St Marianna Univ, Dept Urol, Kawasaki Ku, Kanagawa 2168511, Japan
来源：
TRANSPLANTATION PROCEEDINGS | 2008年 / 40卷 / 10期
关键词：
D O I：
10.1016/j.transproceed.2008.06.110
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We have designed a protocol for ABO-incompatible kidney transplantations based on preoperative plasmapheresis with a tacrolimus/mycophenolate mofetil/methylprednisolone/ basiliximab protocol using low-dose rituximab (200 mg/body) instead of splenectomy to prevent antibody-mediated acute rejection. Eight patients successfully received transplants with this protocol. The titers of anti-A and -B, antibodies as well as the number of CD20(+) cells were readily maintained at a low level posttransplantation. There were no side effects. All patients have renal transplant function with a follow-up of 1-34 months.
引用
收藏
页码：3445 / 3447
页数：3
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