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Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Heavy Ion Radiobiol Res Grp, Radiat Modifier Res Team,Inage Ku, Chiba 2638555, Japan Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Heavy Ion Radiobiol Res Grp, Radiat Modifier Res Team,Inage Ku, Chiba 2638555, Japan