Cu(I)-phosphine complex: An efficient catalyst for synthesis of 3-indole derivatives through one-pot MCR under mild conditions

被引：5

作者：

Prasad, Avvari N. ^{[1
]}

Braga, Felipe C. ^{[1
]}

Lopes, Rosangela da S. ^{[1
]}

Casagrande, Gleison A. ^{[1
]}

de Lima, Denis P. ^{[1
]}

Beatriz, Adilson ^{[1
]}

机构：

[1] Univ Fed Mato Grosso do Sul, Inst Chem, Ave Senador Filinto Muller 1555, BR-79074460 Campo Grande, MS, Brazil

来源：

SYNTHETIC COMMUNICATIONS | 2018年 / 48卷 / 01期

关键词：

3-Substituted indoles; Cu-catalysis; multicomponent reaction; water; Yonemitsu condensation; MULTICOMPONENT REACTIONS; COPPER(I) COMPLEXES; MELDRUMS ACID; ORGANIC-SYNTHESIS; CONDENSATION; INDOLE; CHEMISTRY; ALDEHYDES; ORGANOCATALYSIS; ALKALOIDS;

D O I：

10.1080/00397911.2017.1394467

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient copper (I) halotriphenylphosphine catalyzed one-pot multicomponent reaction (MCR) of 3-substituted indole derivatives has been developed using a variety of aldehydes (aromatic, aliphatic, and heteroaromatic), indole, and active methylene substrates such as malononitrile and ethyl 2-cyano acetate. This reaction proceeds smoothly and obtained good to excellent yields (68-93%) using water as green solvent under ambient conditions. The obtained products were confirmed by H-1, C-13 NMR, and mass spectroscopy techniques. The one-pot MCR occurs through formation of Knoevenagel adducts then followed by Michael addition of indole.

引用

页码：104 / 114

页数：11

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