HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or Vγ9Vδ2 T lymphocytes

被引：1

作者：

Kennedy, Alan ^{[1
]}

Petrasca, Andreea ^{[2
]}

Doherty, Derek G. ^{[2
]}

Hennessy, Martina ^{[1
]}

Spiers, J. Paul ^{[1
]}

机构：

[1] Trinity Coll Dublin, Dept Pharmacol & Therapeut, Sch Med, Dublin, Ireland

[2] Trinity Coll Dublin, Dept Immunol, Sch Med, Dublin, Ireland

来源：

AIDS | 2014年 / 28卷 / 01期

关键词：

CELLS; PROTEIN; MONOCYTES; P38;

D O I：

10.1097/QAD.0000000000000043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-1 Tat exhibits clade-specific cytokine induction in monocytes. We investigated if Tat clades A-D can alter tumour necrosis factor (TNF)- and interferon (IFN)- production by total and V9V2 T cells in vitro. Tat clade B, but not C, augmented TNF- production by THP-1 cells. However, Tat clades A-D did not affect TNF- or IFN- production or secretion by resting or activated conventional and V9V2 T cells. Therefore, transactivation of cytokines by Tat is immune cell-specific.

引用

页码：131 / 136

页数：6

共 26 条

[11] Circulating Vδ1 and Vδ2 T cells in HIV-1-infected patients:: Response to CXCR3 and CXCR4 ligands and to HIV-1 tat
Poggi, A
Fenoglio, D
Murdaca, G
Setti, M
Indiveri, F
Zocchi, R
CLINICAL IMMUNOLOGY, 2005, 115 : S149 - S150
[12] Neutralizing inter-clade cross-reactivity of HIV-1 V1/V2-specific secretory immunoglobulin A in Colombian and French cohorts
Granados-Gonzalez, Viviana
Diana Piedrahita, Leidy
Martinez-Gutierrez, Marlen
Lawrence, Philip
Saoudin, Henia
Zapata, Ximena
Lucht, Frederic
Pinter, Abraham
Genin, Christian
Urcuqui-Inchima, Silvio
Riffard, Serge
AIDS, 2009, 23 (16) : 2219 - 2222
[13] Induction of cross-reactive HIV-1 specific antibody responses by engineered V1V2 immunogens with reduced conformational plasticity
Lai, Jennifer, I
Eszterhas, Susan K.
Brooks, Seth A.
Guo, Chengzi
Zolla-Pazner, Susan
Seaman, Michael S.
Bailey-Kellogg, Chris
Griswold, Karl E.
Ackerman, Margaret E.
VACCINE, 2020, 38 (18) : 3436 - 3446
[14] STUDIES ON IN-VIVO INDUCTION OF HIV-1 ENVELOPE-SPECIFIC CYTOTOXIC T-LYMPHOCYTES BY SYNTHETIC PEPTIDES FROM THE V3 LOOP REGION OF HIV-1 IIIB GP120
NEHETE, PN
CASEMENT, KS
ARLINGHAUS, RB
SASTRY, KJ
CELLULAR IMMUNOLOGY, 1995, 160 (02) : 217 - 223
[15] Double-edged effect of Vγ/Vδ2 T lymphocytes on viral expression in an in vitro model of HIV-1/mycobacteria co-infection
Biswas, P
Ferrarini, M
Mantelli, B
Fortis, C
Poli, G
Lazzarin, A
Manfredi, AA
EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (01) : 252 - 263
[16] Migration of Vδ1 and Vδ2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients:: competition by HIV-1 Tat
Poggi, A
Carosio, R
Fenoglio, D
Brenci, S
Murdaca, G
Setti, M
Indiveri, F
Scabini, S
Ferrero, E
Zocchi, MR
BLOOD, 2004, 103 (06) : 2205 - 2213
[17] Phosphoantigen-reactive Vγ9Vδ2 T lymphocytes suppress in vitro human immunodeficiency virus type 1 replication by cell-released antiviral factors including CC chemokines
Poccia, F
Battistini, L
Cipriani, B
Mancino, G
Martini, F
Gougeon, ML
Colizzi, V
JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (03): : 858 - 861
[18] MUC1-Tn-targeting chimeric antigen receptor-modified Vγ9Vδ2 T cells with enhanced antigen-specific anti-tumor activity
Zhai, Xiaochen
You, Fengtao
Xiang, Shufen
Jiang, Licui
Chen, Dan
Li, Yafen
Fan, Shuangshuang
Han, Zhichao
Zhang, Tingting
An, Gangli
Zhang, Bozhen
Chen, Yusheng
Meng, Huimin
Yang, Lin
AMERICAN JOURNAL OF CANCER RESEARCH, 2021, 11 (01): : 79 - 91
[19] Role of HIV-1 subtype C envelope V3 to V5 regions in viral entry, coreceptor utilization and replication efficiency in primary T-lymphocytes and monocyte-derived macrophages
Vasudha Sundaravaradan
Suman R Das
Rajesh Ramakrishnan
Shobha Sehgal
Sarla Gopalan
Nafees Ahmad
Shahid Jameel
Virology Journal, 4
[20] Deglycosylation or Partial Removal of HIV-1 CN54 gp140 V1/V2 Domain Enhances Env-Specific T Cells
Wan, Yanmin
Liu, Lianxing
Wu, Lan
Huang, Xianggang
Ma, Liying
Xu, Jianqing
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2009, 25 (06) : 607 - 617

← 1 2 3 →