Vascular Contribution to Alzheimer Disease: Predictors of Rapid Progression

被引：9

作者：

Diomedi, Marina ^{[1
]}

Misaggi, Giulia ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Neurosci, Rome, Italy

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2013年 / 12卷 / 04期

关键词：

Alzheimer disease; cerebral blood flow; disease progression; hemodynamics; risk factors; transcranial Doppler; CEREBRAL-BLOOD-FLOW; AMYLOID PRECURSOR PROTEIN; CIRCULATING ANGIOGENIC CELLS; TRANSCRANIAL DOPPLER; COGNITIVE IMPAIRMENT; A-BETA; CEREBROVASCULAR REACTIVITY; NEUROVASCULAR MECHANISMS; BRAIN; DEMENTIA;

D O I：

10.2174/1871527311312040015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Different courses of Alzheimer disease are observed in clinical practice. The rapidly progressive form could be associated with the presence of a major microcirculatory involvement and hemodynamic insufficiency. This short review aims to provide an overview of the current knowledge of cerebrovascular contribution to Alzheimer disease presentation and progression, hypothesizing the possible vascular markers of rapidly progressive form.

引用

页码：532 / 537

页数：6

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