Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia

被引：13

作者：

Nieborowska-Skorska, Margaret ^{[1
,2
]}

Maifrede, Silvia ^{[1
,2
]}

Ye, Min ^{[3
]}

Toma, Monika ^{[1
,2
,4
]}

Hewlett, Elizabeth ^{[3
]}

Gordon, John ^{[3
]}

Bac Viet Le ^{[1
,2
,5
]}

Sliwinski, Tomasz ^{[4
]}

Zhao, Huaqing ^{[6
]}

Piwocka, Katarzyna ^{[5
]}

Valent, Peter ^{[7
,8
]}

Tulin, Alexei V. ^{[9
]}

Childers, Wayne ^{[3
]}

Skorski, Tomasz ^{[1
,2
]}

机构：

[1] Temple Univ, Lewis Katz Sch Med, Dept Microbiol & Immunol, Philadelphia, PA 19140 USA

[2] Temple Univ, Lewis Katz Sch Med, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19140 USA

[3] Temple Univ, Sch Pharm, Moulder Ctr Drug Discovery Res, Philadelphia, PA 19122 USA

[4] Univ Lodz, Fac Biol & Environm Protect, Lab Med Genet, Lodz, Poland

[5] Nencki Inst Expt Biol, Lab Cytometry, Warsaw, Poland

[6] Temple Univ, Dept Clin Sci, Lewis Katz Sch Med, Philadelphia, PA 19122 USA

[7] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria

[8] Med Univ Vienna, Ludwig Boltzmann Cluster Oncol, Vienna, Austria

[9] Univ North Dakota, Dept Biomed Sci, Sch Med & Hlth Sci, Grand Forks, ND 58201 USA

来源：

LEUKEMIA & LYMPHOMA | 2019年 / 60卷 / 04期

基金：

奥地利科学基金会;

关键词：

MECHANISMS;

D O I：

10.1080/10428194.2018.1520988

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1098 / 1101

页数：4

共 15 条

[1] Non-NAD-like PARP-1 inhibitors in prostate cancer treatment
Karpova, Yaroslava
Wu, Chao
Divan, Ali
McDonnell, Mark E.
Hewlett, Elizabeth
Makhov, Peter
Gordon, John
Ye, Min
Reitz, Allen B.
Childers, Wayne E.
Skorski, Tomasz
Kolenko, Vladimir
Tulin, Alexei V.
BIOCHEMICAL PHARMACOLOGY, 2019, 167 : 149 - 162
[2] Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia
Elizabeth Hewlett
Monika Toma
Katherine Sullivan-Reed
John Gordon
Tomasz Sliwinski
Alexei Tulin
Wayne E. Childers
Tomasz Skorski
Medicinal Chemistry Research, 2020, 29 : 962 - 978
[3] Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia
Hewlett, Elizabeth
Toma, Monika
Sullivan-Reed, Katherine
Gordon, John
Sliwinski, Tomasz
Tulin, Alexei
Childers, Wayne E.
Skorski, Tomasz
MEDICINAL CHEMISTRY RESEARCH, 2020, 29 (06) : 962 - 978
[4] PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas
Czyz, Malgorzata
Toma, Monika
Gajos-Michniewicz, Anna
Majchrzak, Kinga
Hoser, Grazyna
Szemraj, Janusz
Nieborowska-Skorska, Margaret
Cheng, Phil
Gritsyuk, Daniel
Levesque, Mitchell
Dummer, Reinhard
Sliwinski, Tomasz
Skorski, Tomasz
ONCOTARGET, 2016, 7 (46) : 75551 - 75560
[5] OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells
Baquero, Juan Miguel
Marchena-Perea, Erik
Mirabet, Rocio
Torres-Ruiz, Raul
Blanco-Aparicio, Carmen
Rodriguez-Perales, Sandra
Helleday, Thomas
Benitez-Buelga, Carlos
Benitez, Javier
Osorio, Ana
FRONTIERS IN ONCOLOGY, 2022, 12
[6] The effect of PARP inhibition on BAX/BAK independent synthetic lethality of BRCA1-deficient non-small cell lung cancer
Paul, I.
Savage, K.
Lamers, E.
Gately, K.
O'Byrne, K. J.
Blayney, J. K.
Kerr, K. M.
Sheaff, M.
Richard, D. J.
Hamilton, P. W.
James, J.
Quinn, J. E.
Fennell, D. A.
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
[7] Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Leukemia Cells
Sullivan, Katherine
Bolton-Gillespie, Elisabeth
Dasgupta, Yashodhara
Langer, Samantha
Siciliano, Micheal
Nieborowska-Skorska, Margaret
Zhao, Huaqing
Valent, Peter
Skorski, Tomasz
BLOOD, 2017, 130
[8] Non-NAD-Like poly(ADP-Ribose) Polymerase-1 Inhibitors effectively Eliminate Cancer in vivo
Thomas, Colin
Ji, Yingbiao
Lodhi, Niraj
Kotova, Elena
Pinnola, Aaron Dan
Golovine, Konstantin
Makhov, Peter
Pechenkina, Kate
Kolenko, Vladimir
Tulin, Alexei V.
EBIOMEDICINE, 2016, 13 : 90 - 98
[9] PARP INHIBITION INDUCES BAX/BAK INDEPENDENT SYNTHETIC LETHALITY OF BRCA1-DEFICIENT NON-SMALL CELL LUNG CANCER
Paul, Ian
Savage, Kienan I.
Blainey, Jaine
Lamers, Elisabeth
Gately, Kathy
Kerr, Keith M.
Sheaff, Michael
Richard, Derek J.
Hamilton, Peter
James, Jackie
O'Byrne, Kenneth J.
Harkin, Paul
Quinn, Jennifer E.
Fennell, Dean A.
JOURNAL OF THORACIC ONCOLOGY, 2011, 6 (06) : S423 - S424
[10] DNA polymerase α-primase facilitates PARP inhibitor-induced fork acceleration and protects BRCA1-deficient cells against ssDNA gaps
Machacova, Zuzana
Chroma, Katarina
Lukac, David
Protivankova, Iva
Moudry, Pavel
NATURE COMMUNICATIONS, 2024, 15 (01)

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