Genetics of Asthma Susceptibility and Severity

被引：20

作者：

Slager, Rebecca E. ^{[1
]}

Hawkins, Gregory A. ^{[1
]}

Li, Xingnan ^{[1
]}

Postma, Dirkje S. ^{[2
]}

Meyers, Deborah A. ^{[1
]}

Bleecker, Eugene R. ^{[1
]}

机构：

[1] Wake Forest Univ Hlth Sci, Ctr Genom & Personalized Med, Winston Salem, NC 27157 USA

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Med, NL-9713 GZ Groningen, Netherlands

来源：

CLINICS IN CHEST MEDICINE | 2012年 / 33卷 / 03期

关键词：

Asthma; Genetics; Susceptibility; Severity; Personalized medicine; Therapy; Lung function; GENOME-WIDE ASSOCIATION; BETA(2)-ADRENERGIC RECEPTOR POLYMORPHISM; IMPROVED LUNG-FUNCTION; SERUM IGE LEVELS; ENVIRONMENT INTERACTIONS; CHROMOSOME; 11Q13.5; SEQUENCE VARIANTS; FUNCTION DECLINE; ADAM33; GENE; LARGE-SCALE;

D O I：

10.1016/j.ccm.2012.05.005

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

This article summarizes major findings in genome-wide studies of asthma susceptibility and severity. Two large meta-analyses identified four chromosomal regions which were consistently associated with development of asthma. Genes that are associated with asthma subphenotypes such as lung function, biomarker levels, and asthma therapeutic responses can provide insight into mechanisms of asthma severity and disease progression. Future genetic studies will incorporate sequencing in comprehensively phenotyped asthmatics to lead to the development of personalized therapy.

引用

页码：431 / +

页数：14

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