Preferential use-dependent block of cardiac late sodium current by ranolazine

被引:0
|
作者
Rajamani, S. [1 ]
El-Bizri, N. [1 ]
Shryock, J. [1 ]
Makielski, J. [2 ]
Belardinelli, L. [1 ]
机构
[1] CV Therapeut Inc, Palo Alto, CA USA
[2] Univ Wisconsin, Madison, WI 53706 USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:31 / 31
页数:1
相关论文
共 50 条
  • [31] Use-dependent block of skeletal muscle sodium current by chiral derivatives of mexiletine and tocainide and antimyotonic activity on ADR mouse.
    DeLuca, A
    Natuzzi, F
    Pierno, S
    Jockusch, H
    Duranti, A
    Lentini, G
    Franchini, C
    Tortorella, V
    Camerino, DC
    BIOPHYSICAL JOURNAL, 1997, 72 (02) : THP72 - THP72
  • [32] Use-dependent inhibition of the cardiac sodium channel Nav1.5 by the opioid oxycodone
    Meents, J.
    Peuckmann-Post, V.
    Lampert, A.
    ACTA PHYSIOLOGICA, 2016, 216
  • [33] Ranolazine inhibits hypoxia-stimulated late sodium current
    Ma, Jihua
    Song, Yejia
    Hu, Liangkun
    Yan, Xisheng
    Zhang, Peihua
    Shryock, John C.
    Belardinelli, Luiz
    FASEB JOURNAL, 2008, 22
  • [34] USE-DEPENDENT BLOCK OF BRAIN SODIUM-CHANNELS BY DESFLURANE AND OTHER GENERAL-ANESTHETICS
    REHBERG, B
    XIAO, YH
    SILVER, RJ
    DUCH, DS
    ANESTHESIOLOGY, 1994, 81 (3A) : A865 - A865
  • [35] Antiarrhythmic action of ranolazine, a late-sodium current blocker
    Chen, Peng-Sheng
    HEART RHYTHM, 2008, 5 (01) : 165 - 165
  • [36] Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner
    Foehr, Karl Josef
    Nastos, Ariadni
    Fauler, Michael
    Zimmer, Thomas
    Jungwirth, Bettina
    Messerer, David Alexander Christian
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [37] LOCAL-ANESTHETICS - EFFECT OF PH ON USE-DEPENDENT BLOCK OF SODIUM CHANNELS IN FROG MUSCLE
    SCHWARZ, W
    PALADE, PT
    HILLE, B
    BIOPHYSICAL JOURNAL, 1977, 20 (03) : 343 - 368
  • [38] Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels
    De Luca, A
    Natuzzi, F
    Desaphy, JF
    Loni, G
    Lentini, G
    Franchini, C
    Tortorella, V
    Camerino, DC
    MOLECULAR PHARMACOLOGY, 2000, 57 (02) : 268 - 277
  • [39] Use-dependent block of sodium channels by local anesthetics is not reduced in a mutant with impaired slow inactivation
    Chen, Yuan
    Yu, Frank
    Scheuer, Todd
    Catterall, William A.
    BIOPHYSICAL JOURNAL, 2007, : 103A - 104A
  • [40] VOLTAGE-DEPENDENT AND USE-DEPENDENT EFFECTS OF LIDOCAINE ON SODIUM CURRENT IN RAT SINGLE VENTRICULAR CELLS
    SANCHEZCHAPULA, J
    TSUDA, Y
    JOSEPHSON, IR
    CIRCULATION RESEARCH, 1983, 52 (05) : 557 - 565