Copper(II)-Mediated Dehydrogenative Cross-Coupling of Heteroarenes

被引：90

作者：

Mao, Zhifeng ^{[1
]}

Wang, Zhe ^{[2
]}

Xu, Zhaoqing ^{[1
,2
]}

Huang, Fei ^{[1
]}

Yu, Zhengkun ^{[1
]}

Wang, Rui ^{[2
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

[2] Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 15期

关键词：

C-H BONDS; COPPER-CATALYZED ARYLATION; GENERAL-METHOD; ARYL BROMIDES; SOLE OXIDANT; PALLADIUM; AZOLES; FUNCTIONALIZATIONS; HETEROCYCLES; ACIDS;

D O I：

10.1021/ol301517y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cu(OAc)(2)-mediated dehydrogenative cross-coupling between two heteroarenes has been realized in the absence of any other additive. A mechanism involving a formal Cu(II) to Cu(0) route by convergent disproportionation of the copper mediator is proposed and has been evidenced by copper mirror formation during the reaction. This synthetic protocol provides a concise and "green" access to unsymmetrical biheteroarenes bearing structural motifs of substantial utility in organic synthesis.

引用

页码：3854 / 3857

页数：4

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