Effect of staphylococcal enterotoxin B injection on the development of experimental autoimmune encephalomyelitis: influence of cytokine and inducible nitric oxide synthase production

被引：8
|
作者：
Kuschnaroff, LM
Overbergh, L
Sefriouni, H
Sobis, H
Vandeputte, M
Waer, M [1 ]
机构：
[1] Katholieke Univ Leuven, Lab Expt Transplantat, Louvain, Belgium
[2] Katholieke Univ Leuven, Rega Inst, Louvain, Belgium
来源：
JOURNAL OF NEUROIMMUNOLOGY | 1999年 / 99卷 / 02期
关键词：
experimental autoimmune encephalomyelitis; superantigens; cytokines; immune tolerance; nitric oxide;
D O I：
10.1016/S0165-5728(99)00024-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Possible mechanisms involved in the protective effect of staphylococcal enterotoxin B (SEB) injection on the subsequent development of experimental autoimmune encephalomyelitis (EAE) were investigated. Only partial clonal deletion and anergy of V beta 8 + T-lymphocytes were documented after myelin basic protein immunization in SEE injected mice. Brain permeability was not influenced. Within the brain or during in vitro rechallenge assays SEB protected mice produced significantly more IL-10, IL-4, TNF-alpha and iNOS. It is suggested that the immune deviating effect of SEE may be involved in its EAE protective effect. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：157 / 168
页数：12
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