A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy

被引：45

作者：

Wang, Zhenzhen ^{[1
,2
]}

Sun, Yonghu ^{[1
,2
]}

Fu, Xi'an ^{[1
,2
,3
]}

Yu, Gongqi ^{[1
,2
,4
]}

Wang, Chuan ^{[1
,2
]}

Bao, Fangfang ^{[1
,2
]}

Yue, Zhenhua ^{[1
,2
,3
]}

Li, Jianke ^{[1
,2
,5
]}

Sun, Lele ^{[1
,2
]}

Irwanto, Astrid ^{[6
]}

Yu, Yongxiang ^{[1
,2
]}

Chen, Mingfei ^{[1
,2
]}

Mi, Zihao ^{[1
,2
]}

Wang, Honglei ^{[1
,2
,3
]}

Huai, Pengcheng ^{[1
,2
,3
]}

Li, Yi ^{[6
]}

Du, Tiantian ^{[1
,2
,5
]}

Yu, Wenjun ^{[1
,2
,5
]}

Xia, Yang ^{[1
,2
,5
]}

Xiao, Hailu ^{[1
,2
]}

You, Jiabao ^{[1
,2
]}

Li, Jinghui ^{[1
,2
]}

Yang, Qing ^{[1
,5
]}

Wang, Na ^{[1
,2
,3
]}

Shang, Panpan ^{[1
,2
]}

Niu, Guiye ^{[1
,2
]}

Chi, Xiaojun ^{[1
,2
,5
]}

Wang, Xiuhuan ^{[1
,2
,5
]}

Cao, Jing ^{[1
,2
,3
]}

Cheng, Xiujun ^{[1
,2
,3
,6
]}

Liu, Hong ^{[1
,2
,5
]}

Liu, Jianjun

Zhang, Furen ^{[1
,2
,3
,4
,5
,7
]}

机构：

[1] Shandong Acad Med Sci, Shandong Prov Inst Dermatol & Venereol, Jinan 250000, Shandong, Peoples R China

[2] Shandong Prov Key Lab Dermatovenereol, Jinan 250000, Shandong, Peoples R China

[3] Shandong Univ, Sch Med, Jinan 250000, Shandong, Peoples R China

[4] Univ Jinan Shandong, Sch Med & Life Sci, Acad Med Sci, Jinan 250022, Shandong, Peoples R China

[5] Shandong Univ, Shandong Prov Hosp Skin Dis, Jinan 250000, Shandong, Peoples R China

[6] Genome Inst Singapore, Human Genet, Singapore 138672, Singapore

[7] Natl Clin Key Project Dermatol & Venereol, Jinan 250000, Shandong, Peoples R China

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

基金：

中国国家自然科学基金;

关键词：

POLYMORPHISMS; POPULATION; RESISTANCE; PROMOTER; MARKERS; GENE;

D O I：

10.1038/ncomms13760

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Leproy, a chronic infectious disease, results from the uncultivable pathogen Mycobacterium leprae (M. leprae), and usually progresses to peripheral neuropathy and permanent progressive deformity if not treated. Previously published genetic studies have identified 18 gene/loci significantly associated with leprosy at the genome-wide significant level. However as a complex disease, only a small proportion of leprosy risk could be explained by those gene/loci. To further identify more susceptibility gene/loci, we hereby performed a threestage GWAS comprising 8,156 leprosy patients and 15,610 controls of Chinese ancestry. Four novel loci were identified including rs6807915 on 3p25.2 (P = 1.94 x 10(-8), OR = 0.89), rs4720118 on 7p14.3 (P = 3.85 x 10(-10), OR = 1.16), rs55894533 on 8p23.1 (P = 5.07 x 10 (-11), OR = 1.15) and rs10100465 on 8q24.11 (P = 2.85 x 10(-11), OR = 0.85). Altogether, these findings have provided new insight and significantly expanded our understanding of the genetic basis of leprosy.

引用

页数：8

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