An Improved Neural Network Ensemble Model of Aldose Reductase Inhibitory Activity

被引：0
|
作者：
Hedayati, B. Keshavarz [1 ]
Parra-Hernandez, R. [1 ]
Laxdal, E. M. [1 ]
Dimopoulos, N. J. [1 ]
Alexiou, P. [2 ]
Demopoulos, V. J. [2 ]
机构：
[1] Univ Victoria, Dept Elect & Comp Engn, Victoria, BC V8W 2Y2, Canada
[2] Aristotle Univ Thessaloniki, Dept Pharmaceut Chem, Thessaloniki, Greece
来源：
2012 INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORKS (IJCNN) | 2012年
基金：
加拿大自然科学与工程研究理事会;
关键词：
DERIVATIVES;
D O I：
暂无
中图分类号：
TP18 [人工智能理论];
学科分类号：
081104 ; 0812 ; 0835 ; 1405 ;
摘要：
In this paper, we improve the results based on a Neural Network-based model that predicts an enzyme (Aldose Reductase) inhibitory activity of a group of compounds. The improvement is due to the judicial selection of ensembles of trained Neural Networks to contribute to the final model. The method is validated on a family of compounds that is different from the families which were used in the training of the model. The results confirm an accurate, chemical-family-independent method that can predict Aldose Reductase inhibitory activity with excellent accuracy.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] A new Neural Network ensemble heuristic for a predictor of the aldose reductase inhibitory activity
    Parra-Hernandez, P
    Laxdal, EM
    Dimopoulos, NJ
    Alexiou, P
    [J]. 2005 IEEE INTERNATIONAL SYMPOSIUM ON SIGNAL PROCESSING AND INFORMATION TECHNOLOGY (ISSPIT), VOLS 1 AND 2, 2005, : 838 - 843
  • [2] Aldose reductase inhibitory activity studies of THERACURMIN
    Dahan, Zeyad A.
    Hussain, Sayyed
    Gyananath, G.
    Zubaidha, P. K.
    [J]. NATURAL PRODUCT RESEARCH, 2018, 32 (18) : 2248 - 2251
  • [3] Synthesis and Aldose Reductase Inhibitory Activity of Botryllazine A Derivatives
    Saito, Ryota
    Ishibashi, Kana
    Noumi, Maiko
    Uno, Sota
    Higashi, Shoko
    Goto, Masaru
    Kuwahara, Shunsuke
    Komatsu, Toshiya
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2019, 67 (06) : 556 - 565
  • [4] The Consensus Ensemble Neural Network Multitarget Model of the RAGE Inhibitory Activity of Chemical Compounds
    Vassiliev, P. M.
    Spasov, A. A.
    Kochetkov, A. N.
    Perfilev, M. A.
    Koroleva, A. R.
    [J]. BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY, 2021, 15 (04) : 281 - 289
  • [5] The Consensus Ensemble Neural Network Multitarget Model of the RAGE Inhibitory Activity of Chemical Compounds
    P. M. Vassiliev
    A. A. Spasov
    A. N. Kochetkov
    M. A. Perfilev
    A. R. Koroleva
    [J]. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 2021, 15 : 281 - 289
  • [6] Synthesis and aldose reductase-inhibitory activity of imidazopyrroloquinoline esters
    Urakami, T
    Tanaka, A
    Tanimoto, T
    Niki, E
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 1996, 44 (08) : 1493 - 1497
  • [7] Review of Medicinal Plants and their Compounds for Aldose Reductase Inhibitory Activity
    Bouknana, Saliha
    Bouhrim, Mohamed
    Ouassou, Hayat
    Bnouham, Mohamed
    [J]. LETTERS IN DRUG DESIGN & DISCOVERY, 2018, 15 (07) : 796 - 812
  • [8] Rat lens aldose reductase inhibitory activity of Aralia continentalis
    Rodriguez, J. P.
    Cho, S.
    Lee, J.
    Lee, K. H.
    Jin, T.
    Kang, K. S.
    Hahm, D. H.
    Huh, C. K.
    Lee, S. C.
    Lee, S.
    [J]. PLANTA MEDICA, 2016, 82
  • [9] Docking and molecular dynamics study on the inhibitory activity of coumarins on aldose reductase
    Wang, Zhiguo
    Ling, Baoping
    Zhang, Rui
    Liu, Yongjun
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 112 (32): : 10033 - 10040
  • [10] Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity
    Matsuda, H
    Morikawa, T
    Toguchida, I
    Yoshikawa, M
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2002, 50 (06) : 788 - 795
12345