Oviz-Bio: a web-based platform for interactive cancer genomics data visualization

被引:18
|
作者
Jia, Wenlong [1 ]
Li, Hechen [1 ]
Li, Shiying [1 ]
Chen, Lingxi [1 ]
Li, Shuai Cheng [1 ,2 ]
机构
[1] City Univ Hong Kong, Dept Comp Sci, Kowloon Tong, Hong Kong 999077, Peoples R China
[2] City Univ Hong Kong, Dept Biomed Engn, Kowloon Tong, Hong Kong 999077, Peoples R China
关键词
MOLECULAR CHARACTERIZATION; WHOLE-GENOME; CELL; INTEGRATION; LANDSCAPE; GENES; EXOME;
D O I
10.1093/nar/gkaa371
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Genetics data visualization plays an important role in the sharing of knowledge from cancer genome research. Many types of visualization are widely used, most of which are static and require sufficient coding experience to create. Here, we present Oviz-Bio, a web-based platform that provides interactive and real-time visualizations of cancer genomics data. Researchers can interactively explore visual outputs and export high-quality diagrams. Oviz-Bio supports a diverse range of visualizations on common cancer mutation types, including annotation and signatures of small scale mutations, haplotype view and focal clusters of copy number variations, split-reads alignment and heatmap view of structural variations, transcript junction of fusion genes and genomic hotspot of oncovirus integrations. Furthermore, Oviz-Bio allows landscape view to investigate multi-layered data in samples cohort. All Oviz-Bio visual applications are freely available at https://bio.oviz.org/.
引用
收藏
页码:W415 / W426
页数:12
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