Systematic review and meta-analysis of mouse models of diabetes-associated ulcers

被引:16
|
作者
Huynh, Pacific [1 ]
Phie, James [1 ]
Krishna, Smriti Murali [1 ]
Golledge, Jonathan [1 ,2 ]
机构
[1] James Cook Univ, Queensland Res Ctr Peripheral Vasc Dis, Townsville, Qld, Australia
[2] Townsville Univ Hosp, Dept Vasc & Endovasc Surg, Townsville, Qld, Australia
基金
英国医学研究理事会;
关键词
transgenic and knockout mice; meta-analysis; ulcer(s); laboratory research in diabetes; WOUND CLOSURE; GROWTH-FACTOR; TOPICAL APPLICATION; OXIDATIVE STRESS; STEM-CELLS; IN-VITRO; IMPROVES; MICE; INFLAMMATION; ANGIOGENESIS;
D O I
10.1136/bmjdrc-2019-000982
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Mouse models are frequently used to study diabetes-associated ulcers, however, whether these models accurately simulate impaired wound healing has not been thoroughly investigated. This systematic review aimed to determine whether wound healing is impaired in mouse models of diabetes and assess the quality of the past research. A systematic literature search was performed of publicly available databases to identify original articles examining wound healing in mouse models of diabetes. A meta-analysis was performed to examine the effect of diabetes on wound healing rate using random effect models. A meta-regression was performed to examine the effect of diabetes duration on wound healing impairment. The quality of the included studies was also assessed using two newly developed tools. 77 studies using eight different models of diabetes within 678 non-diabetic and 720 diabetic mice were included. Meta-analysis showed that wound healing was impaired in all eight models. Meta-regression suggested that longer duration of diabetes prior to wound induction was correlated with greater degree of wound healing impairment. Pairwise comparisons suggested that non-obese diabetic mice exhibited more severe wound healing impairment compared withdb/dbmice, streptozotocin-induced diabetic mice or high-fat fed mice at an intermediate stage of wound healing (p<0.01). Quality assessment suggested that the prior research frequently lacked incorporation of key clinically relevant characteristics. This systematic review suggested that impaired wound healing can be simulated in many different mouse models of diabetes but these require further refinement to become more clinically relevant.
引用
收藏
页数:10
相关论文
共 50 条
  • [21] Risk factors for diabetic foot ulcers: A systematic review and meta-analysis
    Tang, W. H.
    Zhao, Y. N.
    Cheng, Z. X.
    Xu, J. X.
    Zhang, Y.
    Liu, X. M.
    VASCULAR, 2024, 32 (03) : 661 - 669
  • [22] Maggot Therapy in Angiopathic Leg Ulcers: A Systematic Review and Meta-Analysis
    Siribumrungwong, Boonying
    Wilasrusmee, Chumpon
    Rerkasem, Kittipan
    INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS, 2018, 17 (04): : 227 - 235
  • [23] Prevalence of diabetes in Zimbabwe: a systematic review with meta-analysis
    Mutowo, Mutsa
    Gowda, Usha
    Mangwiro, John Chamunorwa
    Lorgelly, Paula
    Owen, Alice
    Renzaho, Andre
    INTERNATIONAL JOURNAL OF PUBLIC HEALTH, 2015, 60 (01) : 1 - 11
  • [24] Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis
    Guasch-Ferre, Marta
    Hruby, Adela
    Toledo, Estefania
    Clish, Clary B.
    Martinez-Gonzalez, Miguel A.
    Salas-Salvado, Jordi
    Hu, Frank B.
    DIABETES CARE, 2016, 39 (05) : 833 - 846
  • [25] Treatments for gestational diabetes: a systematic review and meta-analysis
    Farrar, Diane
    Simmonds, Mark
    Bryant, Maria
    Sheldon, Trevor A.
    Tuffnell, Derek
    Golder, Su
    Lawlor, Debbie A.
    BMJ OPEN, 2017, 7 (06):
  • [26] The use of medicinal plants in venous ulcers: a systematic review with meta-analysis
    Freitas, Anderson L.
    Santos, Carla A.
    Souza, Carlos A. S.
    Nunes, Marco A. P.
    Antoniolli, Angelo R.
    da Silva, Wellington B.
    da Silva, Francilene A.
    INTERNATIONAL WOUND JOURNAL, 2017, 14 (06) : 1019 - 1024
  • [27] Oral administration of mangiferin ameliorates diabetes in animal models: a meta-analysis and systematic review
    Wu, You
    Liu, Wei
    Yang, Tao
    Li, Mei
    Qin, Lingling
    Wu, Lili
    Liu, Tonghua
    NUTRITION RESEARCH, 2021, 87 : 57 - 69
  • [28] A meta-analysis and systematic review of photodynamic therapy for diabetic foot ulcers
    Hou, Chunliu
    Zhang, Lei
    Wang, Lifeng
    Zhao, Sai
    Nie, Jing
    Lv, Mo
    Zhang, Wenjie
    Su, Xuesen
    Tian, Shouyuan
    Li, Yan
    PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2024, 48
  • [29] The prevalence of diabetes in Afghanistan: a systematic review and meta-analysis
    Sohail Akhtar
    Jamal Abdul Nasir
    Amara Javed
    Mariyam Saleem
    Sundas Sajjad
    Momna Khan
    Abdul Wadood
    Khwaja Saeed
    BMC Public Health, 21
  • [30] Diabetes and myocardial fibrosis: a systematic review and meta-analysis
    Salvador, D.
    Gamba, M.
    Gonzales-Jaramillo, V.
    Gonzales-Jaramillo, N.
    Raguindin, P. F.
    Minder, B.
    Graeni, C.
    Wilhelm, M.
    Stettler, C.
    Franco, O. H.
    Muka, T.
    Bano, A.
    EUROPEAN JOURNAL OF HEART FAILURE, 2021, 23 : 271 - 271